Mike,
This is a complicated question :) The floppy bits can contribute to
packing in several non-obvious ways.
I may be able to help you get a better crystal form, if you're willing to
share the specifics of the protein (which will be kept confidential of
course). I've developed new procedures fo
Greetings,
I've taken a protein (structure known) with some disordered termini and
created a new truncated construct that lacks these disordered bits (approx.
5% by mass of the total protein).
To my delight, the new construct crystallizes much more readily than the
full-length one (more hits in
