me from. Also don't if you do.
>> - Don't overparameterise your TLS model, apply Occam's razor, and test
>> for overfitting.
>> - You can check your TLS model with tools like Parvati. Perhaps having
>> more validation tools would be nice.
>>
>> Cheer
Dear all,
trying to be more constructive in this particular discussion concerning TLS, I
remind you an article especially devoted to a question if the applied TLS model
and its results are physically meaningful and, if not (indeed, in very many
cases), how to make them such (if possible) or to
iginal Message-
> > From: CCP4 bulletin board On Behalf Of Gerlind
> > Sulzenbacher
> > Sent: Tuesday, October 29, 2024 17:08
> > To: CCP4BB@JISCMAIL.AC.UK
> > Subject: Re: [ccp4bb] Structures refined ad mentula canis (this is Latin)
> >
> > Dear Italo,
&
Dear Pavel,
thanks for this information.
Nevertheless, I believe that the vast majority of people employed in
macromolecular crystallography laboratories (group leaders, post-docs,
PhDs, and master students) are unable to read and comprehend these articles
due to their extremely superficial kno
7:00:41 AM
> *To:* CCP4BB@JISCMAIL.AC.UK
> *Subject:* Re: [ccp4bb] Structures refined ad mentula canis (this is
> Latin)
>
>
> Dear Pavel,
>
>
> thanks for this information.
>
>
> Nevertheless, I believe that the vast majority of people employed in
> macromol
Dear list members,
the validation of TLS parameters used and refined for a particular model of
a crystal structure was, at one point, the subject of thorough research,
for example:
>From deep TLS validation to ensembles of atomic models built from elemental
motions. II. Analysis of TLS refinement
Dear all,
As I somehow identify with the mention of "some ayatollahs” who perhaps
underwent several rounds of meticulous refinement of demeanor, I fail to see
any wrong to what Oliviero wrote. Oliviero, explains that a third party
proclaimed that "unfortunately, the crystallographic programs be
-Original Message-
> From: CCP4 bulletin board On Behalf Of Gerlind
> Sulzenbacher
> Sent: Tuesday, October 29, 2024 17:08
> To: CCP4BB@JISCMAIL.AC.UK
> Subject: Re: [ccp4bb] Structures refined ad mentula canis (this is Latin)
>
> Dear Italo,
>
> It seems to
Dear Italo,
It seems to me that the ccp4bb has always been a very gentle and
empathic platform of exchange of ideas and offering a great deal of help
to non-experts, "ignorants" as your friend calls them.
I remember that in the late 90thies there were some ayatollahs, which
have become gentl
Dear Oliviero,
many thanks for your timely comment.
I cannot agree more!
Happy retirement!
With all good wishes
Doriano
Il 2024-10-29 16:38 Italo Carugo Oliviero ha scritto:
In a few months, I will retire, because my brain thinks it is still
young but the rest of the body disagrees and think
In a few months, I will retire, because my brain thinks it is still young
but the rest of the body disagrees and thinks the brain is slightly senile.
Of course, I will miss the protein structures very much, so unpredictable
in their insolent beauty.
I have devoted several years of my life to the
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