This seems like a good problem for SAXS rigid body modeling. We previously
used an approach based on docking models into SAXS envelopes with the
constraint of 2-fold symmetry, followed by scoring the dimer models using the
goodness of fit to the experimental curve (1). Another approach would
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Dear Xiao,
you would probably get started with molecular replacement to place one
domain after the other. Once you solved the structure you can use
external restraints to the known structures. If your resolution is
decent and the domains are not disor
Dear all,
I am trying to model a full-length double-domain protein in dimer. The
structure of both N and C terminal domains are known and the linker region
of 5 residues are present in both structure (the linker might be flexible
though). The N-terminal domain's structure is also a dimer, which ca
