Re: [ccp4bb] OT: design of a stable alpha-helical peptide

2024-03-20 Thread Parthasarathy Sampathkumar
Hi Erik, A couple of things to consider: 1. Begin the N-terminus from helix "initiating" residues (i.e. one residue overhang might not be sufficient) 2. If not done already, add the 6-carboxy-fluorescein moiety at C-terminus of the peptide Good Luck, Partha On Wed, Mar 20, 2024 at 6:03 AM Erik Deb

[ccp4bb] OT: design of a stable alpha-helical peptide

2024-03-20 Thread Erik Debler
Hi everyone, Sorry for the off-topic question, but I thought I may get some advice/pointers about the design of a stable alpha-helical peptide. I would like to obtain a peptide mimicking a 13-residue alpha-helix that was identified in a protein to mediate a protein-protein interaction, which is co