Dear All,
The authors of the following paper used molecular replacement of the
substructure to locate the heavy atoms. The known 11-fold symmetry meant that
the heavy atoms had to be in a circle - molecular replacement with circles of
different radii did the trick.
Antson et al. Nature, Vol
Many times when we search for anomalous scatterers, we have some a priori
info about their relative positions. For example, many proteins have
sequence-adjacent methionines, which tether the anomalous scattering
positions to certain distances. Again, there are many heavy atom derivatives
which have
