Jacob,
See Weinreb, et al., 2014 "Enhanced Amino Acid Selection in Fully-Evolved
Tryptophanyl-tRNA Synthetase, Relative to its Urzyme, Requires Domain Movement
Sensed by the D1 Switch, a Remote, Dynamic Packing Motif" JBC 289:4367-4376
for an especially detailed, experimentally and computation
Integrin-ligand binding?
See for example: http://humphrieslab.info/integrins.html
Dr David C Briggs PhD
http://about.me/david_briggs
On 27 Feb 2014 19:43, "Keller, Jacob" wrote:
> Dear Crystallographers,
>
> Does anyone know of good examples of large, reversible conformational
> changes occurr
Hi,
I guess the following paper could be a good example.
''A leukotriene A4 hydrolase-related aminopeptidase from yeast undergoes
induced fit upon inhibitor binding.''
http://www.ncbi.nlm.nih.gov/pubmed/21146536
Best regards,
Mahmudul Hasan
On Mon, Mar 3, 2014 at 6:33 PM, Gustavo Arruda
wrote
Dear Jacob,
we published in 2012 the structures of apo and peptide-bound forms of a
Dipeptidyl peptidase III:
Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6525-30. doi:
10.1073/pnas.1118005109. Epub 2012 Apr 9.
http://www.ncbi.nlm.nih.gov/pubmed/22493238
we observed a mainly rotational motion
Hi Jacob,
This is a paper on a large conformational change upon PLP binding.
http://www.ncbi.nlm.nih.gov/pubmed/22143761
Dear Jacob,
6 phosphogluconate dehydrogenase :-
See Chen et al 2010 J Struct Biol 169,25-35
and for which enzyme there has been a longstanding interest in the protein
dynamics and studies linking with diffuse X-ray scattering: see Biochem Soc
Trans (1986) 14, 653-655.
Best wishes,
John
Prof Jo
Dear CCP4 community -
In case anyone missed this, one interesting example of large conformational
changes associated with ligand binding event(s) is T7 RNA polymerase,
involved in the initiation, elongation and termination of mRNA synthesis
following promoter recognition.
Tom Steitz' review from
Jacob,
Many enzymes do this, not quite as dramatic as calmodulin, but especially
hexokinase, and this is important because it was the origin of Koshland's
"induced fit" idea. Glycogen phosphorylase, aspartate transcarbamylase, and
phosphofructokinase also do radical things involving subunit re
Dear Jacob,
We recently solved crystal structures of apo and ligand bound forms of a
cofactor S-adenosyl-methionine (SAM) dependent methyltransferase RlmJ
(http://nar.oxfordjournals.org/content/41/20/9537.long). Comparison of the
structures revealed that binding of the cofactor and a substrate
Dear Jacob,
Citrate synthase is another early (historically) case, and GAPDH (on binding
NAD).
Andrew
On 27 Feb 2014, at 19:43, "Keller, Jacob" wrote:
> Dear Crystallographers,
>
> Does anyone know of good examples of large, reversible conformational changes
> occurring between ligand-free
Pheromone-binding proteins of lepidopteran moths (Antheraea polyphemus, Bombyx
mori, Amyelois transitella etc.). The C-terminal tetradecapeptide of these
proteins is a random coil in the ligand-bound form, and assumes a helical
structure in the absence of ligand which occupies the binding cavity
Another good example are nucleotide binding proteins - small GTPases
spring to mind, changing between GTP and GDP states and there are many
ATPases such as myosin to name only one of many, cheers, Matt.
On 2014-02-27 20:43, Keller, Jacob wrote:
Dear Crystallographers,
Does anyone know of g
Feb 2014 19:43:01 +
>From: CCP4 bulletin board (on behalf
of "Keller, Jacob" )
>Subject: [ccp4bb] Large Conformational Change Upon Binding
Ligand...
>To: CCP4BB@JISCMAIL.AC.UK
>
>Dear Crystallographers,
>
>Does anyone know of good examples of large, reversible
Trying not to state the obvious but...HIV protease
-Original Message-
From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of Keller,
Jacob
Sent: Friday, 28 February 2014 8:43 a.m.
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] Large Conformational Change Upon Binding Ligand
Dear Crystallographers,
Does anyone know of good examples of large, reversible conformational changes
occurring between ligand-free and -bound states? Could also be a non-relevant
molecule binding, like sulfate or something inducing dubiously -relevant
changes. I already know of the calmodulin
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