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Oggetto: [ccp4bb] How to make covalent bond for modified nucleic acid
Greeting to all,
I am struggling to place modified nucleotides into an oligonucleotide strand. I
built the ligand restraint dictionaries both in Acedrg or Elbow; the generated
liogands look fine, but the covalent
Dear Ai,
Are you trying to make phosphodiester bonds in the main chain? Do your
modified nucleotides follow the standard atom names (P, OP1, OP2, ...,
O3')? If so, you can just change the group name (_chem_comp.group) to
RNA (or DNA). Otherwise you could either change atom names to follow
the stan
Greeting to all,
I am struggling to place modified nucleotides into an oligonucleotide strand. I
built the ligand restraint dictionaries both in Acedrg or Elbow; the generated
liogands look fine, but the covalent bond between the ligand and the
modification site cannot be generated, also in vai
