I've had good luck using the CCP4 DM program PARROT to improve poor
initial MR maps with twinned data. (Based on some suggestions from this
bb.) I think it works especially well if you have a lot of NCS symmetry,
but it's worth a try, and doesn't take long.
Cheers,
___
I would try phase improvement, especially since you have
two molecules per a.u. In other words averaging, solvent
flattning, histogram matching. The best way is to start at
low(er) resoltuion and extend to the highest resolution
vailable. The best criterium for success is a improved and
interpretab
