Re: [ccp4bb] Following up on fragment hits

2015-06-16 Thread Anthony Bradley
com/e-Pharmacophores Hope this helps. Best wishes, Anthony From: CCP4 bulletin board [CCP4BB@JISCMAIL.AC.UK] on behalf of Mo Wong [mowon...@gmail.com] Sent: 16 June 2015 19:38 To: CCP4BB@JISCMAIL.AC.UK Subject: [ccp4bb] Following up on fragment hits Hi

[ccp4bb] Following up on fragment hits

2015-06-16 Thread Mo Wong
Hi all, I have started generating hits from a fragment library that has been screened by SPR, thermal shift and crystallography. We have a few potential allosteric binders that would, for selectivity reasons, be quite interesting if they show modulation of enzyme activity. I am thinking about per