.UK
Betreff: Re: [ccp4bb] AW: appropriate torsion angles
Dear Herman and Paul,
Thanks for your input. I have already looked at the CSD and it conclusively
tells me that both nitrogens are tetrahedral and both have a phenyl ring. I
have added appropriate chiral restraints for the nitrogens.
JISCMAIL.AC.UK] on behalf of
herman.schreu...@sanofi.com [herman.schreu...@sanofi.com]
Sent: Tuesday, April 15, 2014 8:52 PM
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] AW: [ccp4bb] AW: appropriate torsion angles
Dear Paul,
I find it difficult to predict when a pipirazine nitrogen will be sp2 and
@JISCMAIL.AC.UK
Betreff: Re: [ccp4bb] AW: appropriate torsion angles
Dear Joel and Herman,
On 15/04/14 04:39,
herman.schreu...@sanofi.com<mailto:herman.schreu...@sanofi.com> wrote:
Dear Joel,
I always tell our chemists not to include piperazine rings etc. in their
compounds because o
Dear Joel and Herman,
On 15/04/14 04:39, herman.schreu...@sanofi.com wrote:
Dear Joel,
I always tell our chemists not to include piperazine rings etc. in
their compounds because of this conformational mess, but somehow they
do not seem to listen. ;-)
Unfortunately, do did not tell us how
Dear Joel,
I always tell our chemists not to include piperazine rings etc. in their
compounds because of this conformational mess, but somehow they do not seem to
listen. ;-)
Unfortunately, do did not tell us how and with software you auto generated your
cif file, so I can only give some genera
