From: CCP4 bulletin board [CCP4BB@JISCMAIL.AC.UK] on behalf of
herman.schreu...@sanofi.com<mailto:herman.schreu...@sanofi.com>
[herman.schreu...@sanofi.com]
Sent: Tuesday, April 15, 2014 8:52 PM
To: CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK>
Subject: [ccp
Dear Paul,
I find it difficult to predict when a pipirazine nitrogen will be sp2 and when
sp3, so I usually search the csd with the exact substituent at hand and
supposed that Joel will have done the same. In general, I find that auto
generate programs are overly optimistic how far delocalizati
