To paraphrase from our 2018 Acta Cryst D74(6) paper:
“There has been debate as to whether refinement should be performed in real
space or reciprocal space; both approaches have advantages and disadvantages.
In real space, refinement can be performed locally, which has advantages for
computation
Sent: 30 July 2020 13:28:00
To: ccp4bb
Subject: [ccp4bb] AW: [ccp4bb] AW: [EXTERNAL] Re: [ccp4bb] real
real-space-refinement
Hi everybody,
Thank you very much for the many tips! I discovered that in Coot by clicking on
the N- and C-terminus of a protein chain, one can indeed run a real-space
Hi everybody,
Thank you very much for the many tips! I discovered that in Coot by clicking on
the N- and C-terminus of a protein chain, one can indeed run a real-space
refinement on the complete chain and the same is true for a rigid body fit.
However, subsequent refinement with Refmac did not
