2022.
Best wishes,
Mat
Dr Mathew Martin
Cancer Research UK Newcastle Drug Discovery UnitTranslational and Clinical
Research Institute Discovery of Medicines PaulO'Gorman Building Medical
SchoolNewcastle University Framlington Place Newcastle upon TyneNE2 4HHEmail:
mathew.mar...@ncl.ac.u
Dear All,
May I draw your attention to an opportunitythat we have for a talented student
to join our drug-discovery team here at theNorthern Institute for Cancer
Research. The position is a fully-funded PhDstudentship from the EPSRC Centre
for Doctoral Training in Molecular Sciencesfor Me
Hi Randy and Rodger,
We have had real success using BlueSky (MA) for insect expression, I believe we
have had around 15-20 genes synthesis-optimized with these guys. The expression
levels have been rather reasonable too (obviously protein dependent, but on
average 1 mg of xtal grad protein per
Hi Wei,
I'm unsure if this will help, as i've never used it myself, but a former
colleague in France is working on such a server?
http://2p2idb.cnrs-mrs.fr/
But as everyone else has stated, only use this in comparison to some hard
physical data.
Cheers,
Mat
__
Dear Wenhe,
We too have had similar experiences with a couple of other other kinases - CDK2
(PMID: 21291269) and Aurora A (PMID: 22248356), where both soaking and
co-crystallization has resulted in large conformational rearrangement.
Best wishes,
Mat.
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