[ccp4bb] Post-doctoral position in Paris

2015-05-27 Thread CHARBONNIER Jean-Baptiste 137316
Postdoctoral Research Position Structural studies and inhibitors design of NHEJ pathway A 24 month postdoctoral position is available in the Laboratory of Structural Biology and Radiobiology. The group, led by Jean-Baptiste Charbonnier, is located at the CEA Saclay (South Paris) and is part of t

Re: [ccp4bb] offtopic: related to protein purification

2014-08-04 Thread CHARBONNIER Jean-Baptiste 137316
Dear Sonia Your value of 0,1ucal/sec is weak but if you can determine the intial and final plateau and the slope at the transition, it may be ok. Triplicate experiments will give you an idea of the quality of your measurements. Similarly, the control experiments with only the ligand injected i

Re: [ccp4bb] ITC with heterogeneous protein

2014-07-18 Thread CHARBONNIER Jean-Baptiste 137316
Dear Sajid If the binding site of your ligand is remote from the dimerization interface, it should normally not be a problem. You will bind two ligands for a dimer and one ligand for a monomer and you should be able to fit the isotherm with one unique site even in presence of a mix of monomers

[ccp4bb] Postdoctoral position – DNA repa ir - Paris

2008-10-06 Thread CHARBONNIER Jean-Baptiste 137316
Postdoctoral position – Structural Biology of DNA repair A postdoctoral position is available to study DNA repair proteins involved in double-strand break repair. This post-doc is founded by Institut National du Cancer (INCa). All candidates must have a broad experience ranging from bi