ASAP Discovery is approaching a patent disclosure for its preclinical
candidates for its two coronavirus Mpro drug discovery programs. This
competition will mirror some of the real-world drug discovery challenges that
ASAP has had to overcome in the last three years.
This competition will be c
Hi Kavya,
You`r likely working with a very low PI sample, right? . Here are a few
suggestions
Final purification step at a pH closer to the pI:
Adjusting the pH during purification to be closer to the pI can reduce the
solubility and promote precipitation.
Non-PEG precipitants based kits:
Using
Dear CCP4ers,
Wishing you all a Happy New Year!
You may have noticed that the Consurf server has been down since the conflicts
in the Middle East began. Does anyone know of alternative tools that can
provide similar results?
Best regards.
Andre S. Godoy, PhD
Universidade de São Paulo
Instit
Hi Harry
if you mean predicting binding sites, FT map is quite good
Andre S. Godoy, PhD
Universidade de São Paulo
Instituto de Física de São Carlos
Av. João Dagnone, 1100, Jd. Santa Angelina13563-120 - São Carlos, SP, Brazil
Em terça-feira, 3 de janeiro de 2023 12:15:19 BRT, Harry Powel
Dear community,
I would like to know the community opinion in a topicregarding the deposition
of Pandda events maps as part of SF factors of thehits on deposition.
In a recent deposition, I was required by PDB to add to my SFfile a block
containing ‘data for ligand evidence map’, aka Pandda ev
Hi Nicola,
Try TRIS ir bis-tris,
Chers
Em qui, 18 18e jul 18e 2019 às 17:03, Nicola
Evans<251ca3b4615e-dmarc-requ...@jiscmail.ac.uk> escreveu:
I have an unidentfied blob of density at a crystal contact region. I tried
inputting a magnesium ion there, it was clearly incorrect but it i
milar, I'm not convinced that charge
distribution can be that different.Considering that AA is basically the same,
what other factors can be influencing APBS charge calculations? (Ex: rotamers
position, crystal packing, crystallization conditions, etc)
best,
Andre Godoy
IFSC - Univers
al packing is
different from SAXS packing)
Is there any piece of software that can take monomers and find the best (or
least worst) RMSD between a SAXS envelope and a generated coordinate system? Or
anyone have a good ideia for me to do so?
All the best,
Andre Godoy
PhD Student
IFSC - Univers
I keep the additive concentration?, how much
precipitant should I add? how many steps?).
crystal condition: 23% PEG 3350, 0.2M NaCl, 0.1M Tris pH 8.5, 3% galactose
(orthorhombic crystals, with about 0.6 x 0.6 mm)
all the best,
Andre Godoy
Dear All
I'm trying "build_from_scratch" my coot and it doesn't work... the following
error appears, and I really don't know how to fix it:
Connecting to www.ysbl.york.ac.uk|144.32.72.243|:80... connected.
HTTP request sent, awaiting response... 200 OK
Length: 7039 (6.9K) [text/plain]
Saving to
Dear all.
can someone tell me what is the best way to check for ion binding sites on my
structure?
I mean, a text with coordination examples, or maybe a tool on coot for it ...
best wishes
Andre
http://science.loriz.ca/lipids/includes/templates/imagec.html
http://studio-insitu.com/components/com_ag_google_analytics2/games.php?html191
d by my solution criteria (CCall, number of diferent
solutions, site occupancy, or something else...). Also, how I can choose the HA
sites number and resolution cut-off. Many "tutorials" have different awnsers
for those question, so I'm a little lost right now. Any help will be
apreciated!!
Best wishes to all
Andre Godoy
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