Re: [ccp4bb] High-affinity binding Fab to a known epitope amino acid sequence

Hi Samer, SAbDab is an excellent resource for sequence, structure, and affinity data for publicly available antibodies. A quick look shows that Fab-antigen structures 3h42, 2nyy, 4ps4, 2bdn, and 2nz9 all have reported interaction affinities in the low pM range. Probably worth confirming this w

[ccp4bb] Fwd: [ccpem] Tenure track scientist position at PSI (focus on cryo-ET)

Prof. Gebhard F.X. Schertler Structural Biology ETH Zürich D-BIOL Head of Biology and Chemistry Division Paul Scherrer Institut Laboratory of Biomolecular Research, LBR OSRA 007 CH-5232 Villigen PSI gebhard.schert...@psi.ch phone +41 56 310 4265 Anfang der wei

[ccp4bb] High-affinity binding Fab to a known epitope amino acid sequence

Dear All,Sorry to be disturbing you all, however the valuable input I get each time I have an inquiry from the mailing list members, encourages me to inquire again. Do you know of (or use) a Fab with high-affinity of binding to its epitope (KD in the Picomolar pM or the Femtomolar fM range), whe