[ccp4bb] Assistant/Associate Professor Position at the University of Calgary

2021-10-21 Thread Marie Elizabeth Fraser
The Department of Biological Sciences in the Faculty of Science at the University of Calgary is inviting applications for a tenure-track position as an Assistant Professor (or Associate Professor in exceptional circumstances) in Biophysical Chemistry. Qualified applicants are expected to conduct

Re: [ccp4bb] am I doing this right?

2021-10-21 Thread Gergely Katona
Dear Colin, I think you are right: the question is quite open to interpretation. Here is a Bayesian model, which shows that finding 100 pixels with 0 has almost exactly 42% chance (which should come to no surprise to the fans of Hitchhiker’s guide to Galaxy). https://colab.research.google.com/

Re: [ccp4bb] am I doing this right?

2021-10-21 Thread Nave, Colin (DLSLtd,RAL,LSCI)
Congratulations to James for starting this interesting discussion. For those who are like me, nowhere near a black belt in statistics, the thread has included a number of distributions. I have had to look up where these apply and investigate their properties. As an example, “The Poisson distrib

[ccp4bb] Join us for APFED-22: a conference about proteins (April 6th-8th 2022)

2021-10-21 Thread Rhys, Guto Glyn
Hi everyone, Are you interested in protein folding, evolution or design? My colleagues and I are hosting a hybrid conference (online and in-person) in southern Germany on April 6th-8th 2022. Please go to the website https://apfed22.uni-bayreuth.de and follow us on Twitter @apfed2022 for lots of

Re: [ccp4bb] am I doing this right?

2021-10-21 Thread Gergely Katona
I am sorry, this was a dead-end idea multinomial distribution with 0 trials is not defined. Gergely From: CCP4 bulletin board On Behalf Of Gergely Katona Sent: 21 October, 2021 15:29 To: CCP4BB@JISCMAIL.AC.UK Subject: Re: [ccp4bb] am I doing this right? Dear Randy and Kay, My solution would i

Re: [ccp4bb] am I doing this right?

2021-10-21 Thread Gergely Katona
Dear Randy and Kay, My solution would involve a multinomial distribution for assigning the counts to pixels. Something like this: rate ≈ Gamma(1,1) total_counts ≈ Poisson(rate) probs ≈ Dirichlet (alpha=1, for all pixels) pixel_counts ≈ Multinomial (total_counts, probs of the different pixels

Re: [ccp4bb] am I doing this right?

2021-10-21 Thread Randy John Read
Hi Kay, No, I still think the answer should come out the same if you have good reason to believe that all the 100 pixels are equally likely to receive a photon (for instance because your knowledge of the geometry of the source and the detector says the difference in their positions is insignifi

Re: [ccp4bb] am I doing this right?

2021-10-21 Thread Kay Diederichs
Randy, I must admit that I am not certain about my answer, but I lean toward thinking that the result (of the two thought experiments that you describe) is not the same. I do agree that it makes sense that the expectation value is the same, and the math that I sketched in https://www.jiscmail.

Re: [ccp4bb] am I doing this right?

2021-10-21 Thread Randy John Read
Just to be a bit clearer, I mean that the calculation of the expected value and its variance should give the same answer if you're comparing one pixel for a particular length of exposure with the sum obtained from either a larger number of smaller pixels covering the same area for the same lengt

Re: [ccp4bb] am I doing this right?

2021-10-21 Thread Randy John Read
I would think that if this problem is being approached correctly, with the right prior, it shouldn't matter whether you collect the same signal distributed over 100 smaller pixels or the same pixel measured for the same length of exposure but with 100 time slices; you should get the same answer.

Re: [ccp4bb] am I doing this right?

2021-10-21 Thread Kay Diederichs
Hi Ian, it is Iobs=0.01 and sigIobs=0.01 for one pixel, but adding 100 pixels each with variance=sigIobs^2=0.0001 gives 0.01 , yielding a 100-pixel-sigIobs of 0.1 - different from the 1 you get. As if repeatedly observing the same count of 0 lowers the estimated error by sqrt(n), where n is th