Dear Prof. Holton,
An innovative idea; however all of the 30 kb genome may not be useful for
specific detection - SARS-CoV1 and SARS-CoV2 share 80% identity.
A similar fluorescent detection approach for SARS Cov2 -- using the
indiscriminate collateral activity of Cas12 nuclease -- has been report
One problem I see is the sputum, there’s a reason why swabs are made to get
sufficient viral material.
Since stool samples test PCR positive that might be an easier approach to
get sufficient viral material. As a side note, these are not infectious
anymore, or at least one has not been able to inf
In order to do global survelinace of this new virus I figure we're going
to need billions of tests. The biggest barriers I believe are
logistical. Shipping back and forth to a central labs isn't going to
cut it, and neither are test kits that cost $800 each.
I think I may have a plausible wa
I've recently found out the K-index. It's a metric to evaluate the
impact of scientists on twitter vs real life.
https://en.wikipedia.org/wiki/Kardashian_Index
Gianluca Santoni, serial crystallographer
ESRF structural biology group
71 avenue des Martyrs
38027 Grenoble cedex (France)
On 31/0
That's a great news!
But please be aware that those data are extremely anisotropic. The ones
below the detector are partially absorbed by the experimental table.
Your refinement must take this into account!
Gianluca Santoni, serial crystallographer
ESRF structural biology group
71 avenue des
We managed to remove the detector and consequently all the instrument noise
using the same procedure. Remarkable effect - absolutely noiseless images.
We call it the Adjusted Pixel Readout Index Linked effect.
There must be an Ig prize in this.
(shameless but serious plug - our Crystallization
That is awesome. It means we can add data up to a kilometer out, and
start modelling quarks?
I urge the community to deposit all raw data to a virtual detector of
1km in size - I'm sure Google will happily stump up for the storage
costs, the business case is unarguable.
On 01/04/2020 05:
Dear colleagues,
We, the developers of a program for paired refinement, have found a remarkable
feature that should be shared with the community. The fact that data beyond the
arbitrary cutoff may cause an improvement of electron density and make your
models better is generally accepted. We foun
Hi Fellows,
just in time for a little reading during quarantine-induced boredom here
preprint pages
(embargoed until 04.01) from my recent Phys. Rev. paper with a different
take on phasing
https://tinyurl.com/Phys-Rev-2020
Enjoy, BR
--
There are a number of real and/or renowned scientists on twitter and their
share, comments or tips surely inspire and stimulate science. In my novice
understanding, we need good scientists and experts on social platforms, surely
not for publicity or clickbait but for open discussion and directio
1. We need renowned scientists on Twitter because it is one of the best
ways to spread words worth reading, mostly at these times when so many
pseudo-scientists are influencers on social media (or worse, some even have
a show on Netflix).
2. I'm voting for Mass Spec right now
Cheers,
@_biojmg
On T
One remark about Jürgen’s comment (quoted below).
It is great that well established scientists use Twitter, because by doing so
they implicitly accept to be contacted publicly and to engage in public
conversations (assuming their account is public, which is the default when you
sign up on Twitt
I’d agree, but then I would ;-)
@S_M_Lea
Sent from my iPhone
On 31 Mar 2020, at 20:01, Jurgen Bosch wrote:
I personally tweet, and I know a lot of well established scientists that
tweet too.
Don't pretend Twitter is only junk, there are a lot of serious scientist
tweeting good and valuable
If this were a tweet, I would like and retweet it.
-- David
On Tue, 31 Mar 2020 at 20:07, Rangana Warshamanage
wrote:
> What's the purpose of this contest?
> Why one method needs to be crowned over another?
>
> Rangana
>
> On Tue, Mar 31, 2020 at 7:01 PM Gloria Borgstahl
> wrote:
>
>> I person
What's the purpose of this contest?
Why one method needs to be crowned over another?
Rangana
On Tue, Mar 31, 2020 at 7:01 PM Gloria Borgstahl
wrote:
> I personally don't tweet.
>
>
> On Tue, Mar 31, 2020 at 12:21 PM Sweet, Robert <
> 27e0eb9d20ec-dmarc-requ...@jiscmail.ac.uk> wrote:
>
>> Re
I personally tweet, and I know a lot of well established scientists that tweet
too.
Don't pretend Twitter is only junk, there are a lot of serious scientist
tweeting good and valuable information. True there are enough stupid people
tweeting BS.
Jürgen
P.S. Follow me on Twitter @Bosch_Lab
>
I personally don't tweet.
On Tue, Mar 31, 2020 at 12:21 PM Sweet, Robert <
27e0eb9d20ec-dmarc-requ...@jiscmail.ac.uk> wrote:
> Real Men (and possibly Women too) Don't Tweet.
>
> Bob
>
>
> From: CCP4 bulletin board on behalf of James
> Holton
> Sent:
“But we have the BEST ratings!.”
Sent from my iPhone
On Mar 31, 2020, at 12:26 PM, Bernhard Rupp wrote:
EXTERNAL EMAIL – Use caution with any links or file attachments.
So…Science has come down to a popularity contest on social media.
Best, BR
From: CCP4 bulletin board On Behalf Of Aless
So…Science has come down to a popularity contest on social media.
Best, BR
From: CCP4 bulletin board On Behalf Of Alessandro
Vannini
Sent: Tuesday, March 31, 2020 08:42
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] Vote for cryoEM
We are head to head with mass-spectrometry in the #JBCMethodsM
https://www.schrodinger.com/careers
Schrödinger’s mission is to revolutionize drug discovery through the use of
breakthrough computational methods. We are currently looking for outstanding
individuals to join our drug discovery group and contribute to our rapidly
expanding portfolio of
Indeed, centric reflections should have no anomalous signal after merging
Phil
Sent from my iPhone
> On 31 Mar 2020, at 05:48, Kevin Jude wrote:
>
>
> I've had two more helpful responses to this off-list. My crystal is P43212,
> so there are large swaths of centric reflections that I was loo
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