[ccp4bb] RFP for Small Molecule Discovery - AIMS Awards Deadline is October 28th

2019-10-16 Thread Nick DeHaan
Hi CCP4BB, The application deadline for the AIMS Awards program is less than two weeks away! For anyone with a solved protein structure, an AIMS Award can help you discover new small molecule binders. The program is open to investigators, postdocs, and graduate students worldwide. Applications a

[ccp4bb] SAXS Workshop at BioCAT at teh Advanced Photon Source - Second Notice.

2019-10-16 Thread Thomas Irving
BioCAT is offering its fifth intensive HOW-TO course in BioSAXS. Students will have two days of lectures and hands-on software tutorials on the basics of BioSAXS data collection and processing from expert practitioners in the field. This will be followed by data collection on the BioCAT beamline (S

[ccp4bb] Tenure Track Faculty Position in Cell Biology at Florida State University

2019-10-16 Thread Beth Stroupe
Dear CCP4 community, I am pleased to announce the opening of a tenure-track Assistant Professor position in Biological Science at Florida State University, specializing broadly in Cell Biology. Job ID 46496 (https://jobs.omni.fsu.edu/psc/sprdhr_er/EMPLOYEE/HRMS/c/HRS_HRAM_FL.HRS_CG_SEARCH_FL.

Re: [ccp4bb] Issues in new Mac version 10.15

2019-10-16 Thread Werther, Rachel A
Thanks to all who gave advice. The reinstallation of XQuartz worked for me. I was using the most updated version of XQuartz before I reinstalled it, but as Guillaume Gaullier told me: “…macOS updates typically wipe out most files of your XQuartz installation (XQuartz.app will still be where i

Re: [ccp4bb] Figure of merit in refinement

2019-10-16 Thread Randy Read
James, Where we diverge is with your interpretation that big differences lead to small FOMs. The size of the FOM depends on the product of Fo and Fc, not their difference. The FOM for a reflection where Fo=1000 and Fc=10 is very different from the FOM for a reflection with Fo=5000 and Fc=4010

[ccp4bb] AW: [EXTERNAL] Re: [ccp4bb] Figure of merit in refinement

2019-10-16 Thread Herman . Schreuder
Hi James, Did you ever try what happens if you set all the FOMs of e.g. 2vb1 to 1.0 and calculate a map? If you are sure they are not measurement errors they should be included in the map. I would expect some huge ripples, but maybe the "outliers" compensate and you get a truly interesting map.

Re: [ccp4bb] Figure of merit in refinement

2019-10-16 Thread James Holton
All very true Randy, But nevertheless every hkl has an FOM assigned to it, and that is used to calculate the map.  Statistical distribution or not, the trend is that hkls with big amplitude differences get smaller FOMs, so that means large model-to-data discrepancies are down-weighted. I wond

Re: [ccp4bb] Issues in new Mac version 10.15

2019-10-16 Thread William G. Scott
Which ones? All of the binaries in $CBIN I have say "Mach-O 64-bit executable x86_64” So that is unlikely the issue. I haven’t installed Catalina yet, as I only have one computer that is new enough. But one of the changes is they have locked down much of the file system, and are urging i

[ccp4bb] LAST CHANCE: DLS/CCP4 data analysis workshop 2019

2019-10-16 Thread David Waterman
Dear all, Please note the application period for this year's DLS/CCP4 workshop closes *this Friday*. Best wishes -- David -- Forwarded message - From: David Waterman Date: Tue, 1 Oct 2019 at 15:30 Subject: DLS/CCP4 data analysis workshop 2019 To: PhD students, postdocs and e

Re: [ccp4bb] Issues in new Mac version 10.15

2019-10-16 Thread Ruud Hovius
Hello, this is the warning that our IT people gave us : *"Do not *install the MAcOS upgrade to the new system CATALINA This system version will apparently NOT allow 32-bit applications to run, which are still many , see https://support.apple.com/en-us/HT208436 Try to go back to the former