Hi all,
We have a Research Technician position for 11 months initially, in
professor B.A. Wallace's lab to work on cloning, membrane protein
expression and purification, binding assays to small molecules and
co-crystallisation.
The full job descriptions and details of how to apply are in th
Dear Chandra, we are also currently getting quotes for a new microscope.
I recently worked at Oak ridge with a Zeiss SteREO Discovery.V20
https://www.zeiss.com/microscopy/us/products/stereo-zoom-microscopes/stereo-discovery-v20.html
(everything motorized, which is not really needed) and at diamo
Dear all,
A postdoctoral position is available in the Karakas lab at Vanderbilt
University School of Medicine. Our group is interested in understanding the
molecular mechanism of intracellular ion channels involved in calcium signaling
using structural biology approaches. More details of the pr
(Apologies for the reposting, the web-link now work correctly)
Hello everyone,
The Frederick National Laboratory for Cancer Research (FNLCR, operated by
Leidos Biomedical Research for NCI) is looking for a Team Lead/Senior
Scientist (Computational Chemistry).
FNLCR serves as the hub for the NCI
Oops. I meant to say that Ca2+ usually has seven coordinating atoms.
Mg2+ usually has six. Sorry for the error.
-Daniel
On Wed, Mar 7, 2018 at 2:27 PM, Daniel M. Himmel, Ph. D. <
danielmhim...@gmail.com> wrote:
> Rajesh,
>
> Ca2+ usually is coordinated by five atoms, whereas Mg2+ usually is
>
I would not rely only on coordination numbers, since Ca2+ can be also
hepta-coordinated. You can look at the high resolution structures of
parvalbumin and nucleoside hydrolases. And, although not up to date, this site
is also useful http://mespeus.bch.ed.ac.uk/tanna/ . The anomalous map
sugges
Rajesh,
Ca2+ usually is coordinated by five atoms, whereas Mg2+ usually is
coordinated by six. I've seen that a lot in structures that I've
determined.
-Daniel
On Wed, Mar 7, 2018 at 2:14 PM, Eleanor Dodson <
176a9d5ebad7-dmarc-requ...@jiscmail.ac.uk> wrote:
> You just calculate a anom ma
You just calculate a anom map - it doesnt need you to dselect Ca or Mg or
anything else..
Judge the peak heights by the signal you get over any S sites in the model.
The relative signal you expect depends on your wavelength of course.
Eleanor
On 7 March 2018 at 19:09, Rajesh Kumar wrote:
> Hi I
Hi Ivan,
https://csgid.org/csgid/metal_sites/
suggest that Mg++ is the correct metal. Ca++ is not acceptable.
I am going to validate it by calculating anomalous peak for Ca++ too.
Thank you
Rajesh
On Wed, Mar 7, 2018 at 1:06 PM, Ivan Shabalin <
iva...@iwonka.med.virginia.edu> wrote:
> Hi, Raj
Hi, Rajesh,
It does look like Ca to me. It has around 2.4 A distances to waters and
quite many electrons (18), which correspond to rather wide and high
density peak in the middle.
Mg has distances at 2.07, and 10 electrons (should be a smaller peak).
Na has 2.41 distances to waters, 10 elect
Dear all,
*A two-year postdoctoral fellowship, funded by the Carl Tryggers
Foundation, is available in the group of Julia Griese in the Department
of Cell and Molecular Biology at Uppsala University, Sweden. *
Research in the Griese lab is at the intersection of structural biology,
molecular
Hi Chandra
My only comment is be careful of modern microscopes that have a frosted
glass screen with LEDs behind it, just below the plate. For looking at
crystals you need *directional *light. I've seen some very expensive
modern microscopes with illumination that just doesn't work for
crystalli
Careina,
Feel free to contact me about these things without using the CCP4BB list.
I am sending this to the list with as purpose that others might in the
future refer people with questions about homology modelling to me. After
all, although the possibility to build homology models is one of th
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