Dear all,
Please find attached an advert for a Ph.D. studentship to apply structural
biology and inhibitor design
to tackle protein arginine methyl transferases in a collaboration between the
departments of chemistry and
the Northern Institute for Cancer Research.
Best wishes,
Martin Noble
Hi Christian,
I usually send the pdb back to the tlsmd server after any manipulation of the
model just to be on the safe side. I'm not sure whether that'll make any
difference in your case but it's perhaps worth trying.
Cheers,
Boaz
Boaz Shaanan, Ph.D.
Dept. of Life Sciences
Hi Christian, I've seen this behaviour as well. I'm not an expert but I
rationalized the situation as the TLS parameters for an incomplete model
getting overfit as the missing/wrong parts of the model pull on the TLS
parameters. REFMAC doesn't alternate between TLS and coordinate refinement,
so you
Hi all,
I refine a structure with TLS and restrained refinement in Refmac. After
the run finished, I fixed a few outliers manually in Coot, saved that
file and used that with the original TLS file from TLSMD for the next
round of refinement. As soon as the restrained refinement starts the
R-f
Just what it says - if you look at the log file (search for $TABLE) you
will see a resolution bin has no reflections. Maybe your data is very
incomplete at high resolution? Maybe the cell is very smal and you can
reduce the numbers of bins..
So suggestions would be - change the resolution range, r
In running refmac (restrained refinement, P21 space group, 68-1.94 Angstrom
data), the program stops with the error:
Refmac_5.8.0103: No reflections in resolution bin ???
Any idea what is causing this?
Manal A. Swairjo, Ph.D.
Assistant Professor
Graduate College of Biomedical Sciences
Weste
