> I have never heard of this happening (or seen a structure where there was
> density for this type of adduct)
Maybe it is kind of textbook-knowledge? BMC p48 Fig 2-27
http://www.ruppweb.org/garland/gallery/Ch2/index_2.htm
BR
Does anyone know whether or not this is possible, and why it does
Just a quick self-correction, the P(+3) in the previous post should be P(-3)
-- I type too fast :) and of course, while the final product of this
reaction is P(+5) the likely salient intermediate product is in fact P(-1)
in the form of R3P=O (which undergoes further interesting reactions.
Artem
O
Thank you for such great explanation. Hopefully people won't consider me
hijacking this thread.
Nian
On Sun, Apr 17, 2011 at 11:08 AM, Artem Evdokimov wrote:
> TCEP relies on a completely different chemistry to achieve the same goal as
> BME or DTT.
> DTT/BME use S(-)>SS with redox potentials of
TCEP relies on a completely different chemistry to achieve the same goal as
BME or DTT.
DTT/BME use S(-)>SS with redox potentials of -0.26 to -0.33 V (at pH 7)
whereasTCEP uses P(3+)->P(5+) oxidation with redox potential that's a lot
higher (I don't know of a reference with a stated redox potential
