Re: [Bioc-devel] edgeR and limma Default Offsets

2017-02-15 Thread Ryan Thompson
They wouldn't be exactly consistent even if they used the same prior count, since the calculations are not identical. edgeR normalizes the prior count by each library's normalization factor so that log fold changes are always squeezed toward zero, while voom, if I understand correctly, does not nor

[Bioc-devel] edgeR and limma Default Offsets

2017-02-15 Thread Dario Strbenac
Good day, The cpm function in edgeR uses a default offset of 0.25 and voom in limma uses 0.5 (and provides no user modification) to calculate the base 2 logarithm of the counts per million. Might these be made consistent? -- Dario Strbenac University of Sydne

Re: [Bioc-devel] Problem on malbec2 server

2017-02-15 Thread Romero, Juan Pablo
Thanks Herv�. I will wait to do another version bump until all the servers are updated. Yes, the package suggests knitr. in order to build vignettes correctly. Thanks - Juan Pablo From: Herv� Pag�s Sent: Tuesday, February 14, 2017 11:26 PM To: Romero, Juan P