[NMusers] FW: Intersubject Variability in Logistic Regression
> From: Garimella, Tushar > Sent: Friday, January 25, 2013 3:43 PM > Subject: Intersubject Variability in Logistic Regression > > Dear NONMEM-users, > > We are working on a logistic regression problem using a dichotomous response > (1 observation per subject, either 0 or 1) and came across the following > control stream in the NM Users Guide: > > $PROB DICHOTOMOUS RESPONSE > $DATA data > $INPUT ID DOSE DV > $PRED > LOGIT=THETA(1)+THETA(2)*DOSE**THETA(3)+ETA(1) > A=EXP(LOGIT) > P=A/(1+A) > IF (DV.EQ.1) THEN > Y=P > ELSE > Y=1-P > ENDIF > $THETA .1 (25,100) (1,3,5) > $OMEGA 1 > $ESTIMATION MET=COND LAPLACE LIKE MAX=500 > $SCAT ETA(1) VS DOSE > > We are discussing the role and interpretation of the ETA as shown in the > control stream in the context of logistic regression (for example: is it > appropriate to estimate intersubject variability in logistic regression, and > how can this be interpreted with dichotomous data) and would like to seek > input from the group. > > Thank you in advance for your help > > Best regards, > > Tushar > > >
RE: [NMusers] FW: Intersubject Variability in Logistic Regression
Dear Tushar, With only one observation per subject and dichotomous data, there is not enough information to estimate intersubject variability. Logistic regression without interindividual variability is a simple estimation problem doesn't need any approximation (Laplace or so). In NONMEM you can just specify > $ESTIMATION MET=0 LIKE MAX=500 You should omit or rename the "ID" column, as NONMEM would expect ETAs when ID as in the data set. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Phyllis Hui-Min Chan Sent: 26 January 2013 13:39 To: nmusers@globomaxnm.com Subject: [NMusers] FW: Intersubject Variability in Logistic Regression > From: Garimella, Tushar > Sent: Friday, January 25, 2013 3:43 PM > Subject: Intersubject Variability in Logistic Regression > > Dear NONMEM-users, > > We are working on a logistic regression problem using a dichotomous response (1 observation per subject, either 0 or 1) and came across the following control stream in the NM Users Guide: > > $PROB DICHOTOMOUS RESPONSE > $DATA data > $INPUT ID DOSE DV > $PRED > LOGIT=THETA(1)+THETA(2)*DOSE**THETA(3)+ETA(1) > A=EXP(LOGIT) > P=A/(1+A) > IF (DV.EQ.1) THEN > Y=P > ELSE > Y=1-P > ENDIF > $THETA .1 (25,100) (1,3,5) > $OMEGA 1 > $ESTIMATION MET=COND LAPLACE LIKE MAX=500 > $SCAT ETA(1) VS DOSE > > We are discussing the role and interpretation of the ETA as shown in the control stream in the context of logistic regression (for example: is it appropriate to estimate intersubject variability in logistic regression, and how can this be interpreted with dichotomous data) and would like to seek input from the group. > > Thank you in advance for your help > > Best regards, > > Tushar > > >
Re: [NMusers] When will NONMEM UsersNet Archive be searchable again?
There is an alternative: http://www.mail-archive.com/nmusers@globomaxnm.com/ On Sat, Jan 26, 2013, at 07:52 AM, Joachim Grevel wrote: [1]http://www.cognigencorp.com/index.php/cognigen/resources_nonmem Dear NONMEM users, For several months now I cannot search the NONMEM usersnet archive. Can somebody please tell me where the problem lies? Many thanks, Joachim Joachim Grevel, PhD Scientific Director BAST Inc Limited Loughborough Innovation Centre Charnwood Building Holywell Park, Ashby Road Loughborough, LE11 3AQ Tel: +44 (0)1509 222908 Confidentiality Notice: This message is private and may contain confidential and proprietary information. If you have received this message in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this message is not permitted and may be unlawful. References 1. http://www.cognigencorp.com/index.php/cognigen/resources_nonmem -- Alison Boeckmann alisonboeckm...@fastmail.fm
RE: [NMusers] When will NONMEM UsersNet Archive be searchable again?
Many thanks Alison, This works like a charm! Joachim From: Alison Boeckmann [mailto:alisonboeckm...@fastmail.fm] Sent: 26 January 2013 16:30 To: jgre...@bastinc.eu; nmusers Subject: Re: [NMusers] When will NONMEM UsersNet Archive be searchable again? There is an alternative: http://www.mail-archive.com/nmusers@globomaxnm.com/ On Sat, Jan 26, 2013, at 07:52 AM, Joachim Grevel wrote: http://www.cognigencorp.com/index.php/cognigen/resources_nonmem Dear NONMEM users, For several months now I cannot search the NONMEM usersnet archive. Can somebody please tell me where the problem lies? Many thanks, Joachim Joachim Grevel, PhD Scientific Director BAST Inc Limited Loughborough Innovation Centre Charnwood Building Holywell Park, Ashby Road Loughborough, LE11 3AQ Tel: +44 (0)1509 222908 Confidentiality Notice: This message is private and may contain confidential and proprietary information. If you have received this message in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this message is not permitted and may be unlawful. -- Alison Boeckmann alisonboeckm...@fastmail.fm
