[ccp4bb] Postdoctoral position at the Karolinska Institute: Deadline March 5, 2025

[Opher Gileadi]

Postdoctoral fellow in protein production/structural biology. 

https://ki.varbi.com/what:job/jobID:795999/ 

We are seeking a highly skilled and motivated post-doctoral research fellow in 
protein production/
structural biology, to join an international open science project in 
translational medical research. The
project aims to investigate under-studied human genes as potential drug targets 
through generation of
open-access knowledge and high-quality research tools. Part of this includes 
the expansion of the
chemical switching technology that was recently established at Karolinska. This 
is an exciting
opportunity to work on producing and characterizing novel human protein 
variants and recombinant
antibodies to human targets, using a combination of molecular biology, 
biochemistry and structural
biology. We offer a multi-national and collaborative research environment at 
the EUbOPEN projects
with partners in academia and the biomedical industry worldwide.
This position is jointly supervised by Maurice Michel and Opher Gileadi.



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[ccp4bb] Off topic: Consumables for microscale thermophoresis

[Markus Seeliger]

Dear All,
We are using the nanotemper MST for protein-ligand interactions and I
wanted to explore alternative sources for the nanotemper capillaries and
their labeling dyes. They are rather pricey in the US compared to the EU
and the labeling kits work less well in our hands than labeling with
similar chemistry from other sources.
Thank you for your insights.

Markus Seeliger



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[ccp4bb] Registration Open. Macromolecular Crystallography School, Madrid (May 12–16, 2025)

[Armando Albert]

Dear all,
 
Registration is now open for the next edition of the Macromolecular 
Crystallography School, taking place in Madrid from May 12 to May 16, 2025.
 
Since 2010, this workshop has been organized at the Instituto de Química Física 
Blas Cabrera (CSIC) and is designed for 25 graduate students and researchers 
with prior expertise in crystallography and/or Cryo-EM who seek deeper insight 
into advanced structural biology techniques.
 
The program covers key topics such as sample preparation, structure solution, 
model building, crystallographic refinement, validation, and analysis of 
structural results, along with an overview of the latest advancements in 
structural biology. Additionally, this edition will include: The impact of 
Artificial Intelligence on structure solution and low-resolution refinement, 
Dynamic Crystallography at XFEL and synchrotron facilities, Ligand Building for 
drug discovery.
 
Participants will also have the unique opportunity to learn from and contact 
with world-leading researchers in Macromolecular Crystallography and Cryo-EM, 
who will share their expertise. 
 
For more details, please visit our website: 
https://www.xtal.iqf.csic.es/MCCS2025/ 

We look forward to seeing you in Madrid!
 
Best regards,
 
Armando
 
Organizers:
Armando Albert, Juan A. Hermoso, María J. Sánchez-Barrena, and Lourdes Infantes
Departamento de Cristalografía y Biología Estructural
Instituto de Química Física "Blas Cabrera"
Consejo Superior de Investigaciones Científicas (CSIC)
Serrano 119, 28006 Madrid, Spain
 


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