[ccp4bb] Data Science Roles @ GSK

[Duncan Johnstone]

Hi,

We are currently recruiting for two Data Science roles at GSK, which may appeal 
to individuals with a background in crystallographic software development.
These roles are part of a new Data & Predictive Sciences function and in the 
team that I lead, delivering data science solutions for Target Discovery and 
Human Genetics & Genomics.

Team Leader, Data Sciences - Protein, Cellular & Structural Sciences and 
Chemical Biology
Team Leader Data Sciences - Protein, Cellular & Structural Sciences and 
Chemical Biology in Multiple Locations | GSK 
Careers

Investigator, Data Sciences - Target Discovery and Human Genetics & Genomics
Investigator Data Sciences -Target Discovery and Human Genetics & Genomics in 
Multiple Locations | GSK 
Careers

If you are interested in either of these roles, please do make an application 
and feel free to reach out.

Thanks

Duncan


[cid:image001.png@01DA7082.E263ED70]


Duncan Johnstone
Director of Data Science - Target Discovery and Human Genetics & Genomics

Data & Predictive Sciences

E  duncan.n.johnst...@gsk.com
M +447833 200698

[cid:image002.png@01DA7082.E263ED70]

[cid:image003.png@01DA7082.E263ED70]
[cid:image004.png@01DA7082.E263ED70]
[cid:image005.png@01DA7082.E263ED70]




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[ccp4bb] PhD Positions in Mainz/Germany

[Wolf, Eva]

Dear all,

2 PhD positions are available immediately in the research group of Eva Wolf in 
Mainz (Germany). Research in the Wolf group is focused on the structural, 
biochemical and biophysical analyses of proteins involved in the circadian 
(day-time dependent) and circalunar (monthly) regulation of cellular, 
physiological and behavioral processes. We recently described molecular 
mechanisms and Cryo-EM structures of a marine cryptochrome (L-Cry), which is 
involved in the synchronization of moon-controlled maturation rhythms of marine 
worms with the lunar cycle (Pöhn, Krishnan et al, Nat Comm 2022; Vu, Behrmann 
et al, Nature Comm 2023; Zurl et al, PNAS 2022). The prospective PhD students 
will further characterize LCry’s reponses to sunlight and moonlight and its 
molecular interactions with downstream ligands. In a highly interdisciplinary 
approach, they will apply a wide range of techniques including UV/VIS 
spectroscopy, biochemical and biophysical protein interaction studies, protein 
expression and purification, X-ray crystallography, Cryo-EM, pulldown/MS, 
molecular biology and functional cell-based assays.

Candidates with a strong interest in structural biology, protein biochemistry, 
biophysics and structure-function relationship and a significant previous 
exposure to these research areas during their master education are encouraged 
to apply. Please send your application including your CV, motivation letter, 
certificates and contact details for two referees in one pdf file to Eva Wolf 
(evawo...@uni-mainz.de). We encourage PhD 
candidates to also apply to the International PhD Program (IPP) of the Mainz 
Institute of Molecular Biology (IMB) before April 17th. Information about the 
IPP can be found under 
https://www.imb.de/students-postdocs/international-phd-programme/apply-to-ipp .

-

Prof. Dr. Eva Wolf

Structural Chronobiology

University and IMB Mainz

Hanns-Dieter-Hüsch-Weg 17

55128 Mainz, Germany

evawo...@uni-mainz.de

https://chrono-wolf.biologie.uni-mainz.de/




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[ccp4bb] Postdoc position available

[Gabriel Demo]

Dear all,

We seek a talented individual to fill a postdoctoral position (at the Central 
European Institute of Technology (CEITEC), Masaryk University Brno, Czech 
Republic.) with expertise in the field of cryo-electron microscopy and 
translation regulation. Ideal candidates should possess a solid foundation in 
biochemistry or structural biology, particularly in single-particle 
cryo-electron microscopy or protein crystallography.

For more details, please visit our website 
https://demolab.ceitec.cz/
 and the postdoctoral position offer 
https://www.ceitec.eu/postdoctoral-fellow-in-the-research-group-of-gabriel-demo/j500.

To apply, please submit your CV, along with contact information for three 
referees, and a brief motivational letter to recruitm...@ceitec.muni.cz. The 
deadline for applications is June 30th, 2024.

Best regards,

--



Mgr. Gabriel Demo, PhD. | CEITEC MU

Junior Group Leader



tel: +420 549 49 7827

e-mail: gabriel.d...@ceitec.muni.cz

web: www.ceitec.cz



Masarykova univerzita

Central European Institute of Technology

Kamenice 5, 625 00 Brno

Kancelář A35/1S155



#CEITECScience

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Re: [ccp4bb] Mystery blob

[Diana Tomchick]

It’s the Easter Bunny!

But seriously, it looks like more than one compound, perhaps hydrogen bonded to 
each other.

Diana Tomchick

Sent from my iPhone

On Mar 7, 2024, at 7:32 AM, Eleanor Dodson 
<176a9d5ebad7-dmarc-requ...@jiscmail.ac.uk> wrote:


EXTERNAL MAIL

Anyone ANY idea what this could be?? Beautiful density but...

I am told:
The possible/likely components of the protein solution/cryo/crystallisation 
buffer are:
NaCl, MES, a tiny bit of HEPES possibly, ligand ( GR8.027 = the pentasaccharide 
near catalytic residues Glu276 and Glu165), Et3N which is monomer TEA (a 
possible counterion for the ligand - see diagram below), glycerol (cryo)
There may also be carbonate ions present from the ligand.  Any thoughts 
appreciated!!



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UT Southwestern

Medical Center

The future of medicine, today.



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[ccp4bb] PDRA position in structural biology at Diamond Light Source, 3 year fixed term, vacancy closing 10/03/2024

[Flaig, Ralf (DLSLtd,RAL,LSCI)]

A reminder that this vacancy will be closing on 10/03/2024.

https://vacancies.diamond.ac.uk/vacancy/postdoctoral-research-associate-structural-biology-502687.html


We now have an opportunity for an experienced molecular structural biologist, 
at Post-Doctoral Research Associate level, to further support the structural 
biology activity
on the I04 beamline in the field of chromatin remodelling and histone 
modification.
These projects are pursued as part of the Diamond inhouse research programme 
and in collaboration with university partners.

Suitable candidates will hold an appropriate first degree and PhD and 
demonstrate proven relevant experience. We are looking for an experienced
molecular biologist or biochemist with experience or a strong interest in 
structural biology and biophysical methods. Experience in a
structural biology method (X-ray crystallography, cryo-EM, SAXS) would be 
highly beneficial, and a keen interest in pursuing an integrated structural 
biology approach is expected.

The candidate will join the team at the Diamond variable and microfocus 
macromolecular crystallography beamline I04 
(https://www.diamond.ac.uk/Instruments/Mx/I04.html) ,
which is part of the MX Group at Diamond and offers capabilities for tackling 
challenging problems in structural biology. The MX group at Diamond presents
7 world-leading MX beamlines with unique capabilities and is complemented by 
dedicated beamlines for bioSAXS, CD, X-ray imaging and spectroscopy,
IR-microspectroscopy, 3D Correlative Cryo-Imaging and the electron Bio-Imaging 
Centre (eBIC). In addition, the MX group has established the first dedicated
X-ray fragment screening lab (XChem) and an XFEL hub which hosts users, and 
coordinates XFEL experiments. There is a strong software development
programme that includes lead development of the DIALS integration software 
package, ISPyB/Synchweb and automation pipelines as well as
collaborative projects with CCP4 and CCP-EM. This is complemented by provision 
of state-of-the-art laboratories for structural biology within
the Research Complex at Harwell. Together with other world leading facilities 
(ISIS, CLF) on the campus and the Rosalind Franklin Institute (RFI)
the Harwell Science and Innovation Campus site offers a stimulating and highly 
multidisciplinary environment.

More details and how to apply can be found here:

https://vacancies.diamond.ac.uk/vacancy/postdoctoral-research-associate-structural-biology-502687.html


--
Dr. Ralf Flaig
ralf.fl...@diamond.ac.uk
Principal Beamline Scientist, I04 Macromolecular Crystallography
Diamond Light Source, Harwell Science and Innovation Campus
Chilton, Didcot OX11 0DE, United Kingdom
tel: +44 (0)1235 77 8412 fax: +44 (0)1235 77 8448
http://www.diamond.ac.uk/mx-home/
https://www.diamond.ac.uk/Instruments/Mx/I04.html





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