[ccp4bb] Job opening at ModeX

[Ronnie]

ModeX Therapeutics is seeking a highlyskilled and motivated scientist to 
support biologics production, characterization,and optimization for developing 
innovative biotherapeutics. This is an excitingopportunity to be part of a 
cross-functional team and contribute to thedevelopment of next-generation 
biological therapeutics in a fast-paced, rapidlygrowing biotech company with a 
bold vision. 

Company 

ModeX Therapeutics, a subsidiary of OPKOHealth, is a biotech based in 
Massachusetts dedicated to the concept ofmodulating multiple disease targets 
with innovative multi-targeting strategies.It was founded by Dr. Elias Zerhouni 
and Dr. Gary J. Nabel in 2020 with a teamof scientists with proven track record 
from early research to clinicaldevelopment, regulatory approvals, and 
commercialization. ModeX is pursuing thedevelopment of novel immune-oncology 
therapeutics for cancers and biotherapeuticsagainst infectious disease.

Major responsibilities

·Interact closely and be part ofinterdisciplinary biologics research 
teams to drive the discovery of innovative therapeutic antibodies and 
theoptimization of their biochemical and biophysical properties.

·Contribute to ModeX’s multi-targetingstrategy through structure-based 
antibody design, production, andcharacterization platforms.

·Develop a high-throughputantibody expression and purification platform 
and lead the effort in producing high-qualitymultispecific antibodies for 
developability assessment and PK/PD studies. 

·Perform biochemical andbiophysical characterization of diverse 
biologics molecules, includingmulti-specifics, fusion proteins, and non-viral 
particle to support leadcandidate selection, focusing on antibody’sbiophysical 
properties including chemical stability, solubility,polyspecificity and 
polyreactivity. 

·Interpret results and present/communicatewith cross-functional 
colleagues for successful execution and completion ofprojects.

·Stayscientifically current and contribute to the implementation of new 
technologyand instrumentation.

·Ensure effective andtimely documentation in electronic laboratory 
notebooks.

Qualifications

·PhD or MS in biochemistry,structure biology, biomedical engineering, 
or other life science disciplines

·Minimum of 3 years (PhD)/6 years (MS) of relevant experiences 

·Knowledge in antibodystructure and the development of antibody-based 
biotherapeutics is preferred.

·Skilled in protein expressionin mammalian cells and protein 
purification using various chromatographymethods and instruments such as AKTA 
FPLC.

·Experience with proteinanalytic techniques such asHPLC/UPLC, 
cIEF/CE-SDS, SLS/DLS, and BLI/SPR based protein-protein 
interactioncharacterization is a plus.

·Excellent written andoral communication, organization, and data 
analysis skills.  Outstanding troubleshooting and problem-solvingskills.

·Highly adaptable to afast-paced work environment and capable to work 
both independently andcollaboratively within project teams. 

To apply, please send cover letter and CVto hao.c...@modextx.com and 
care...@modextx.com




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[ccp4bb] Staff Scientist opening at UT Health San Antonio

[Taylor, Alexander Bryan]

Dear Colleagues,


The University of Texas Health Science Center at San Antonio is seeking a Staff 
Scientist to support the protein production capabilities of its Structural 
Biology Core Facilities 
(SBC). The Protein 
Production Facility has infrastructure for recombinant protein production in 
bacterial, insect, and mammalian expression systems and is fully equipped for 
protein purification and characterization. The Protein Production Facility is 
closely integrated with the X-ray, NMR, and cryo-EM facilities of the SBC and 
will provide the successful candidate with opportunities to develop experience 
and skills in these techniques.


Interested candidates should email a curriculum vitae, a list of three 
references and a cover letter addressed to Dr. Shaun K. Olsen at 
ols...@uthscsa.edu. Review of applications will begin immediately upon receipt 
and will continue until the position is filled.


Thank you,


Alex

 --
Alex Taylor, Ph.D.
Assistant Professor/Research, Department of Biochemistry & Structural Biology
Associate Director, Structural Biology Core Facilities
University of Texas Health Science Center at San Antonio



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