[ccp4bb] 2 postdoctoral fellowships available to study Type 4 Secretion Systems at Umeå University, Sweden

[Ronnie Berntsson]

Dear colleagues,

I have two postdoctoral fellowships available in my group.  Please see below 
for the details and feel free to spread it to anyone you think might be 
interested and suitable for the positions.

Best wishes,
Ronnie


Postdoctoral fellowships to study Type 4 Secretion System

The Berntsson lab at the department of Medical Biochemistry and Biophysics at 
Umeå University, Sweden, is looking to recruit up to two postdoctoral fellows 
(2-year projects) to study the structural and functional aspects of Type 4 
Secretion Systems. These large protein complexes are responsible for horizontal 
gene transfer between bacteria. As such, they facilitate the spread of, among 
other genes, antibiotic resistance between bacteria, both intra- and 
interspecies.
The overall goals of these particular projects are to continue the structural 
and functional characterisation, already begun in the lab, of the i) the 
adhesion proteins and ii) the DNA processing proteins of G+ Type 4 Secretion 
Systems. The projects will involve molecular biology, biochemistry and 
structural biology techniques, with an early emphasis on the functional 
characterization of these proteins and their complexes.
Qualifications
The applicants must possess a PhD, or another diploma deemed equivalent to a 
PhD, within molecular biology, biochemistry, structural biology or a related 
field. Furthermore, the applicant shall have practical experience and expertise 
of cloning and protein production and purification in bacteria. The applicant 
should preferably be experienced with functional studies of (membrane) proteins 
using various molecular biology and biochemical methods, such as ITC, SPR, 
fluorescence spectroscopy and microscopy, as well as having experience with 
protein crystallography. Previous experience of working with membrane proteins 
is an advantage, as is previous experience of fluorescence microscopy and 
electron microscopy. The applicants must have a very good level of English, 
both written and spoken. The applicants are also expected to be good team 
players, but should also be able to work independently.
Application
The application should consist of the following:

1. A short (maximum 1 A4 page) cover letter, explaining the motivation to 
apply for the position.

2. The Curriculum Vitae of the applicant, including a list of published 
peer-reviewed articles.

3. Copies of the PhD diploma (or equivalent).

4. Contact details for three references, of which one should be your PhD 
supervisor.

The duration of the fellowship is 2 years. Your application should be written 
in English and prepared as a package in PDF format, to be submitted to 
ronnie.bernts...@umu.se. Make sure to use the 
subject line: “postdoc application T4SS” in the application email. Submit the 
application on January 15, 2019 at the latest. The top ranked candidates will 
be contacted within three weeks from the closing date for an interview. 
Starting date according to agreement. For more information, contact Dr. Ronnie 
Berntsson.
Email: ronnie.bernts...@umu.se
Webpage: https://www.biostruct.umu.se/principal-investigators/ronnie-berntsson/




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[ccp4bb] Lab technician position available at NIH

[Jacey Chen]

The Roll-Mecak lab at the National Institutes of Health has an opening for
a lab technician to work on protein expression in human and SF9 cells as
well as work under the mentorship of a postdoc on projects related to
structural biology of microtubule regulators. Basic skills in molecular
biology are required. Experience with tissue culture is preferred but not
required.



Our lab is a dynamic and very friendly group. The position is perfect for
someone that has an enthusiasm to learn and loves scientific research. You
will also benefit from the vibrant academic environment and terrific
research resources that NIH offers.



The job is full-time and located at the NIH Bethesda main campus, Maryland,
which is only 20 min to the DC downtown area by metro. Please visit our lab
website for more information. ( *https://neuroscience.nih.gov/ninds/rm_lab/
*)



Requirements for the position,

1.The candidate should have a B.S. degree in Biology, Biochemistry or
other related areas.

2.At least 1 year of lab experience in one of these areas: molecular
biology, tissue culture or biochemistry.



Please contact Jiayi Chen (jiayi.c...@nih.gov) with your CV and names of
three referees if you are interested in the position.



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[ccp4bb] PhD positions available in structural biology at the University of Manitoba

[Gerd Prehna]

Dear colleagues,

I am looking for enthusiastic MSc or PhD students to join my group in the 
Department of Microbiology at the University of Manitoba, Canada 
(https://home.cc.umanitoba.ca/~prehnag/). 

Our lab studies how bacteria communicate with their hosts, how they communicate 
with each other, and how they communicate with other micro-organisms. The 
supported graduate student positions are aimed at understanding the adaptation, 
versatility, and host-specificity of Type VI secretion systems (T6SS) at the 
molecular level using Salmonella as a model system. A MSc or PhD student will 
research the role of one or more accessory proteins that modulate the function 
of the Salmonella T6SS(s) using structural, biochemical, and molecular biology 
techniques. 

Applicants should possess or be near completion of a Bachelor’s degree in the 
life sciences or a related discipline, and be interested in both biochemistry 
and microbiology. Some experience in molecular biology as well as protein 
expression and purification is desired but not required. Training in x-ray 
crystallography and NMR spectroscopy will be provided. All projects have the 
potential for training in cryo-EM. English language skills, the ability to work 
in a team, willingness to learn, and good organizational skills are required.

Applications should include: 
1. The applicant's CV
2. A one-page summary of their motivation for pursing graduate studies
3. Contact details for at least two references

Please send application materials by January 15th, 2019 to:

gerd.pre...@umanitoba.ca 

The starting date is spring 2019. 

The University of Manitoba (http://umanitoba.ca/) is located in Winnipeg, 
Manitoba and is Western Canada’s first University. The University has large 
core-group of structural biology and biochemical researchers between the 
departments of Microbiology (http://www.sci.umanitoba.ca/microbiology/) and 
Chemistry (The Manitoba Group in Protein Structure and Function), access to the 
Canadian Light Source synchrotron, and comprehensive molecular biophysics 
instrumentation (500 and 600 MHz NMR, in-house XRD, ITC, CD, DSC, AUC, and 
MST). Winnipeg is also home to the National Microbiology Laboratory, a leader 
in infectious disease research and collaborator with the Department of 
Microbiology. 



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[ccp4bb] Survey for the CCP4 community study

[LE DU Marie-Hélène]

Dear CCP4 users ,

Not only is CCP4 a historical project born to promote the collaborative 
development of software dedicated to crystallography, but it has played a key 
role in building the biological crystallography community and remains an 
international reference and a keystone.
CCP4 also represents a very valuable teaching community through interactions 
between newcomers and experts.
Following the French MOOC " Voyage au coeur du vivant avec les rayons X : la 
cristallographie." "("A journey I the heart of life with X-ray: 
crystallography"), I have initiated an analysis of CCP4 as a teaching community.
In order to complete this analysis, your contribution would be very useful. 
Thank you in advance for completing the following short survey (5-10 min):
https://docs.google.com/forms/d/1JMP9HISMefYOYDm077VgALrVJWo7vqRuUvhW1wqbk8s/edit

Best regards

Marie-Hélène Le Du

Attention, nouvelles coordonnées :
CEA/DRF/JOLIOT/I2BC, UMR 9198
Bâtiment 21, Avenue de la Terrasse
91190 Gif-sur-Yvette
France
E-mail : 
marie-helene.l...@i2bc.paris-saclay.fr
Tel : (33) (0)1 69 82 46 73






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Re: [ccp4bb] Survey for the CCP4 community study

[Robbie Joosten]

Hi Marie-Hélène,

Thanks for having such a wide 5-20 years category. Keeps me from feeling really 
old ;)
I can honestly say that I've learned a lot on the BB and that some of the 
discussions have really broadened my knowledge beyond the standard books. I try 
to pay it forward whenever I can.
It is wonderful that we have a community where the oldest members are four 
times as old as the youngest ones and many people contribute not just knowledge 
and insight, but also historical perspective on our long-standing field.

Cheers,
Robbie

Cheers,
Robbie

On 17 Dec 2018 19:19, LE DU Marie-Hélène 
 wrote:

Dear CCP4 users ,



Not only is CCP4 a historical project born to promote the collaborative 
development of software dedicated to crystallography, but it has played a key 
role in building the biological crystallography community and remains an 
international reference and a keystone.

CCP4 also represents a very valuable teaching community through interactions 
between newcomers and experts.

Following the French MOOC " Voyage au coeur du vivant avec les rayons X : la 
cristallographie." "("A journey I the heart of life with X-ray: 
crystallography"), I have initiated an analysis of CCP4 as a teaching community.

In order to complete this analysis, your contribution would be very useful. 
Thank you in advance for completing the following short survey (5-10 min):

https://docs.google.com/forms/d/1JMP9HISMefYOYDm077VgALrVJWo7vqRuUvhW1wqbk8s/edit



Best regards



Marie-Hélène Le Du



Attention, nouvelles coordonnées :

CEA/DRF/JOLIOT/I2BC, UMR 9198

Bâtiment 21, Avenue de la Terrasse

91190 Gif-sur-Yvette

France

E-mail : 
marie-helene.l...@i2bc.paris-saclay.fr

Tel : (33) (0)1 69 82 46 73







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Re: [ccp4bb] Survey for the CCP4 community study

[Eleanor Dodson]

I am an old hand at the BB - I guess I am both a methodoligist (Sp?) and
formerly a software developer.
You can only develop useful software if you continuously liase with users -
it is all too easy to produce a beautiful artefact that no-one either wants
or can use easily. And all too easy to fail to spot the bugs in your
code..The BB has been one of the valuable links between users and
developers, and gives us all a quick and straightforward way to communicate
.

I am proud of the way developers are now putting real effort in to
reporting results, and providing a meaningful analysis of potential
problems. But this sort of online guideance needs user response too - is it
comprehenible? Is it accurate?  etc etc.

It will be interesting if you can stimulate debate about these issues.

Thank you
Eleanor Dodson

On Mon, 17 Dec 2018 at 19:01, Robbie Joosten 
wrote:

> Hi Marie-Hélène,
>
> Thanks for having such a wide 5-20 years category. Keeps me from feeling
> really old ;)
> I can honestly say that I've learned a lot on the BB and that some of the
> discussions have really broadened my knowledge beyond the standard books. I
> try to pay it forward whenever I can.
> It is wonderful that we have a community where the oldest members are four
> times as old as the youngest ones and many people contribute not just
> knowledge and insight, but also historical perspective on our long-standing
> field.
>
> Cheers,
> Robbie
>
> Cheers,
> Robbie
>
> On 17 Dec 2018 19:19, LE DU Marie-Hélène <
> marie-helene.l...@i2bc.paris-saclay.fr> wrote:
>
> Dear CCP4 users ,
>
>
>
> Not only is CCP4 a historical project born to promote the collaborative
> development of software dedicated to crystallography, but it has played a
> key role in building the biological crystallography community and remains
> an international reference and a keystone.
>
> CCP4 also represents a very valuable teaching community through
> interactions between newcomers and experts.
>
> Following the French MOOC " Voyage au coeur du vivant avec les rayons X :
> la cristallographie." "("A journey I the heart of life with X-ray:
> crystallography"), I have initiated an analysis of CCP4 as a teaching
> community.
>
> In order to complete this analysis, your contribution would be very
> useful. Thank you in advance for completing the following short survey
> (5-10 min):
>
>
> https://docs.google.com/forms/d/1JMP9HISMefYOYDm077VgALrVJWo7vqRuUvhW1wqbk8s/edit
>
>
>
> Best regards
>
>
>
> *Marie-Hélène Le Du*
>
>
>
> *Attention, nouvelles coordonnées :*
>
> CEA/DRF/JOLIOT/I2BC, UMR 9198
>
> Bâtiment 21, Avenue de la Terrasse
>
> 91190 Gif-sur-Yvette
>
> France
>
> E-mail : *marie-helene.l...@i2bc.paris-saclay.fr
> *
>
> Tel : (33) (0)1 69 82 46 73
>
>
>
>
>
> --
>
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
>
>
>
> --
>
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
>



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Re: [ccp4bb] Survey for the CCP4 community study

[Robert Sweet]

Dear Eleanor, you are certainly The Queen of the CCP4BB!!  Thanks for 
infinite patience!


Bob

On Mon, 17 Dec 2018, Eleanor Dodson wrote:


I am an old hand at the BB - I guess I am both a methodoligist (Sp?) and
formerly a software developer.
You can only develop useful software if you continuously liase with users -
it is all too easy to produce a beautiful artefact that no-one either wants
or can use easily. And all too easy to fail to spot the bugs in your
code..The BB has been one of the valuable links between users and
developers, and gives us all a quick and straightforward way to communicate
.

I am proud of the way developers are now putting real effort in to
reporting results, and providing a meaningful analysis of potential
problems. But this sort of online guideance needs user response too - is it
comprehenible? Is it accurate?  etc etc.

It will be interesting if you can stimulate debate about these issues.

Thank you
Eleanor Dodson

On Mon, 17 Dec 2018 at 19:01, Robbie Joosten 
wrote:


Hi Marie-Hélène,

Thanks for having such a wide 5-20 years category. Keeps me from feeling
really old ;)
I can honestly say that I've learned a lot on the BB and that some of the
discussions have really broadened my knowledge beyond the standard books. I
try to pay it forward whenever I can.
It is wonderful that we have a community where the oldest members are four
times as old as the youngest ones and many people contribute not just
knowledge and insight, but also historical perspective on our long-standing
field.

Cheers,
Robbie

Cheers,
Robbie

On 17 Dec 2018 19:19, LE DU Marie-Hélène <
marie-helene.l...@i2bc.paris-saclay.fr> wrote:

Dear CCP4 users ,



Not only is CCP4 a historical project born to promote the collaborative
development of software dedicated to crystallography, but it has played a
key role in building the biological crystallography community and remains
an international reference and a keystone.

CCP4 also represents a very valuable teaching community through
interactions between newcomers and experts.

Following the French MOOC " Voyage au coeur du vivant avec les rayons X :
la cristallographie." "("A journey I the heart of life with X-ray:
crystallography"), I have initiated an analysis of CCP4 as a teaching
community.

In order to complete this analysis, your contribution would be very
useful. Thank you in advance for completing the following short survey
(5-10 min):


https://docs.google.com/forms/d/1JMP9HISMefYOYDm077VgALrVJWo7vqRuUvhW1wqbk8s/edit



Best regards



*Marie-Hélène Le Du*



*Attention, nouvelles coordonnées :*

CEA/DRF/JOLIOT/I2BC, UMR 9198

Bâtiment 21, Avenue de la Terrasse

91190 Gif-sur-Yvette

France

E-mail : *marie-helene.l...@i2bc.paris-saclay.fr
*

Tel : (33) (0)1 69 82 46 73





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--
=
Robert M. Sweet   E-Dress:  sw...@bnl.gov
Deputy Director, LSBR: The Life Science and ^ (that's L
  Biomedical Technology Research Center at NSLS-II   not 1)
Photon Sciences and Biology Dept
Office and mail, Bldg 745, a.k.a. LOB-5
Brookhaven Nat'l Lab. Phones:
Upton, NY  11973  631 344 3401  (Office)
U.S.A.631 338 7302  (Mobile)
=



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[ccp4bb] Structural Biology Position at Evotec (U.S.)

[Brooks, Mark]

Dear All,
Due to continued expansion, there is an opportunity to join the 
Structural Biology team at Evotec (US) based at Princeton, New Jersey, as a 
Senior Scientist (Structural Biology).
Please see the advert in the link below. Interested candidates should apply 
directly through Zip Recruiter & please do not send applications through to me 
directly.

https://www.ziprecruiter.com/jobs/evotec-473c889a/senior-scientist-protein-purification-structural-biology-f3e5dcbf

Best wishes,

Mark

www.evotec.com
Evotec (U.S.) Inc
Building 303B,
College Road East,
Princeton,
NJ 08540,
USA.


STATEMENT OF CONFIDENTIALITY.

This email and any attachments may contain confidential, proprietary, 
privileged and/or private information.  
If received in error, please notify us immediately by reply email and then 
delete this email and any attachments from your system. Thank you!


https://www.evotec.com/en/about/site-information/data-protection-uk

Evotec (UK) Ltd is a limited company registered in England and Wales. 
Registration number:2674265. Registered office: 114 Innovation Drive, Milton 
Park, Abingdon, Oxfordshire, OX14 4RZ, United Kingdom.



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[ccp4bb] Postdoctoral position at Drug Discovery Institute at Purdue University

[John M Hausman]

Dear All:

A position is available for a highly qualified and motivated  postdoc with a 
strong background in Molecular/Cell Biology or Immunology. The successful 
applicant will be responsible for conducting research aimed at identifying and 
characterizing new drug targets for treatment of important human diseases.  
Activities may involve i) expressing and characterizing proteins that are 
upregulated in various disease states, ii) cloning, mutating, expressing and 
developing assays for studying functional aspects of the target proteins, iii) 
immunofluorescent staining of tissue sections from diseased tissues, iv) shRNA 
knockdown of desired proteins in cultured cells, and v) immunoblotting and 
other common biochemical assays.  Management of day-to-day research goals and 
priorities, supervision of graduate students assigned to the same project, and 
mentoring of other research personnel regarding the design and execution of 
specific research methods/approaches may also be required.

The lab is directed by Professor Philip S. Low in the new Drug Discovery 
Institute on the West Lafayette Campus of Purdue University.  Other members of 
the lab are involved in designing new therapies for cancer, fibrotic diseases, 
infectious diseases, sickle cell disease, bone fractures and related 
pathologies, and autoimmune diseases, etc.  Participation in some of these 
existing projects may also be required.

Please send CV and list of three names of potential referees to:

Philip S. Low
Presidential Scholar for Drug Discovery
Ralph C. Corley Distinguished Professor
Department of Chemistry
Purdue University
720 Clinic Dr.
West Lafayette, IN 47907
Email: p...@purdue.edu







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[ccp4bb] Cryo EM at ETH

[Schertler Gebhard (PSI)]

https://www.ethz.ch/content/dam/ethz/special-interest/dual/scopem/PDFs/Senior%20scientist%20-%20expert%20in%20Cryo%20Electron%20Microscopy%20(002).pdf





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Senior scientist - expert in Cryo Electron Microscopy (002).pdf
Description: Senior scientist - expert in Cryo Electron Microscopy (002).pdf
Prof. Gebhard F.X. SchertlerStructural Biology ETH Zürich D-BIOLHead of Biology and ChemistryDivisionPaul Scherrer InstitutLaboratory of Biomolecular Research, LBROFLC 109CH-5232 Villigen PSIgebhard.schert...@psi.chphone +41 56 310 4265


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