As another data point, I always had trouble running gentoo-prefix / 
lemona.de on Fedora. More often than not it caughed up some error about 
file ownership/permissions and errored out. 

Fundamentally, I think a user-space package manager like conda or hashdist 
is sufficiently different from a system-level package manager. E.g. for the 
former it is perfectly fine to blow away the entire managed file tree and 
reinstall, which doesn't really work on the system level. The latter has 
lots of other duties (like file ownership/permissions) which require admin 
access.

As another example, rpm can also act as user-space package manager. Its 
just that everybody has long given up on building relocatable rpms and it 
has long gotten used to having admin access, so its a theoretical 
possibliity at best. 



On Friday, March 11, 2016 at 8:14:13 PM UTC+1, François wrote:
>
> In early 2011 we had a working version of sage on gentoo-prefix on OS X 
> via sage-on-gentoo. 
> Then the situation degraded as apple “support” for gcc vanished. 
> At the moment we have a working toolchain based on clang on gentoo prefix 
> but 
> no working fortran compiler as far as I can see. 
> I tried to work on bringing a pre made gfortran but definitely lack the 
> time to do so. 
> So at the moment sage-on-gentoo-prefix on OS X is indeed stopped. 
>
> François 
>   
> > On 12/03/2016, at 04:01, Francesco Biscani <blues...@gmail.com 
> <javascript:>> wrote: 
> > 
> > With that said, my experiences with the prefix version of gentoo on OSX 
> have been a bit of a mixed bag. It felt to me like it was very close to be 
> generally viable, but a lot of manual tweaking was still needed. I have no 
> experiences with it on Windows platforms, but I think it does have some 
> support for cygwin. 
>
>

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