I love my Schwalbe Duremes (700 x 50 mm) and how smooth they are on paved/packed road yet handle all the single track I've tossed their way well. If I were doing a trip that involved a lot of mud or sand, I'd likely want a fat bike. But no flats in the 18 months I've used them. They're discontinued, but their replacements seem pretty good as well. I love their handling and especially not having to deal with flats.
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