Pharmacokinetic and pharmacodynamic modeling and simulation By Dr. Jan Freijer March 18, 2010 Amsterdam, The Netherlands
http://www.can.nl/events/details.php?id=57 This course is aimed at users of R or S-PLUS in the bio-pharmaceutical sciences who would like to use R for clinical trial simulations. topics include Working with packages in R - MASS - odesolve Random generation from univariate distributions - density, distribution function, quantile function and random generation - various distributions Random generation from multivariate distributions - normal distribution - working with the covariance matrix - simulating PK and PK-PD model parameters Solving differential equations - solving differential equations in R - testing the numerical solution versus analytical solution - PK models for single dose oral or IV administration - PK models for multiple dose oral or IV administration - implementing PD models Clinical trial simulations - combining the structural model with the random effects model - uncertainty versus variability - example: two compartment PK model with indirect response model Location: Amsterdam Date : March 18th Time : 10:00h.-16:30h. Price : EURO 395,- excluding VAT Register: - phone : +31-(0)20-560-8400 - Email : pau...@can.nl - Web : http://www.can.nl/events/details.php?id=57 There is a maximum of 12 participants. You may register by replying to this email and provide us with the following information. Name : M / F Title : Department : Institute : Address : City : Zip : Telephone : Fax : Email : Please let us know if you have any questions. Please feel free to send this message on to your colleagues and friends for whom it might be interesting!! Kind regards, Dick Verkerk _________________________ CANdiensten, Nieuwpoortkade 23-25, NL-1055 RX Amsterdam tel: +31 20 5608410 fax: +31 20 5608448 verk...@candiensten.nl _________________________ Your Partner in Mathematics and Statistics! ______________________________________________ R-help@r-project.org mailing list https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting-guide.html and provide commented, minimal, self-contained, reproducible code.
