On Dec 4, 2009, at 9:29 AM, Ashta wrote:

Hi All,

I am trying to run the following script  but have problem,

coxm<- coxph(Surv(sdat$time, sdat$cens)~hd+nawtg+nwwg+ntpg+cy +nseas,data=sdat)
coxm<-stepAIC(coxm,~.^2)

The error message is
Error: could not find function "stepAIC"

Perhaps you have not loaded the package that contains that function?



I tried to install the package but I could not find it. Where can i get it?


The other question is that I want to get the Kaplan-Meier Estimate
for each covariate in the model,

Not exactly sure what that means. Kaplan-Meier estimate of ... what?
Like
covaraite   n     Events   Mean, S.E.(mean) ,Median, 95% LCL, 95% UCL
  0             14      10       2.87       .03              2.2
   1.938         infi
  1             11      9          1.06      .67              1.1
    0.29           2.48

I used

sdat.fit0 <- survfit(Surv(sdat$time, sdat$cens)~sdat$ntpg, data = sdat,
type = "kaplan-meier", conf.type="plain")
sdat.fit0

Instead I got the following,


Call: survfit(formula = Surv(sdat$time, sdat$cens) ~ sdat$ntpg, data = sdat,
   type = "kaplan-meier", conf.type = "plain")

                      records  n.max   n.start  events   median
0.95LCL   0.95UCL
sdat$ntpg=0 3576 3576 3576 311 NA NA NA sdat$ntpg=1 4851 4851 4851 466 NA NA NA

If you have a dataset with 300-400 events out of 3000-4000 subject, then why are you expressing surprise that you do not get a non- parametric estimate of the median survival? The median is the time at which half of the subjects would have experienced an event and you only have 1/10 of them with events.

--

David Winsemius, MD
Heritage Laboratories
West Hartford, CT

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