ADDENDUM: I managed though with the LL4 and LL5 algorithms:
```
mod = drm(Response~Dose, data = df, fct=LL.4())
plot(mod)
```
what would be the difference with the Hill function?
Thank you
On Thu, Sep 25, 2025 at 1:41 PM Luigi Marongiu <marongiu.lu...@gmail.com> wrote:
>
> Hello,
> it was an assembler problem of the machine. I now managed to install
> the package, I tried to fit a 4 or 5 parameters model but the fitting
> is not good:
>
> ```
> df = data.frame(Response = c(890.72, 890.94, 880.16,
> 895.46, 890.8, 884.15,
> 895.63, 887.22, 879.57, 894.72,
> 888.91, 878.89,
> 895.49, 890.83, 882.27, 893.59,
> 889.92, 881.59,
> 892.53, 891.76, 880.98, 895.06,
> 890.32, 881.45,
> 897.21, 886.35, 876.19, 889.27,
> 878.11, 868.32,
> 876.05, 866.57, 859.16, 850.53,
> 857.96, 859.34,
> 862.02, 859.04, 859.73, 858.36,
> 863.64, 861.19),
> Dose = c(0.0000000015, 0.0000000015,
> 0.0000000015, 0.000000003,
> 0.000000003, 0.000000003, 0.000000006,
> 0.000000006,
> 0.000000006, 0.000000012, 0.000000012,
> 0.000000012,
> 0.000000024, 0.000000024, 0.000000024,
> 0.000000048,
> 0.000000048, 0.000000048, 0.000000095,
> 0.000000095,
> 0.000000095, 0.00000018, 0.00000018,
> 0.00000018, 0.00000038,
> 0.00000038, 0.00000038, 0.00000078,
> 0.00000078, 0.00000078,
> 0.0000015, 0.0000015, 0.0000015,
> 0.000007, 0.000007,
> 0.000007, 0.000025, 0.000025,
> 0.000025, 0.00005, 0.00005, 0.00005)
> )
> plot(Response~log10(Dose), df)
> library(drc)
> mod = drm(Response~Dose, data = df, fct=L.4())
> plot(mod)
> ```
> How can I set a Hill function with `drm`?
> Thank you
>
> On Thu, Sep 25, 2025 at 1:01 PM varin sacha <varinsa...@yahoo.fr> wrote:
> >
> > Hi,
> >
> > What about directly calling the model function with basicdrm library ?
> >
> > library(basicdrm)
> >
> > # Fit Hill model
> > m <- drm(Response ~ Dose, data = df, fct = hillfct())
> >
> > summary(m)
> >
> > # Predict & plot
> > plot(m, log = "x")
> >
> > Best,
> > SV
> >
> > > Le 25 sept. 2025 à 10:12, varin sacha via R-help <r-help@r-project.org> a
> > > écrit :
> > >
> > >
> > > Hi,
> > > Could you paste me the exact error message you’re getting when trying
> > > install.packages("drc")
> > >
> > >
> > >> Le 25 sept. 2025 à 09:02, Luigi Marongiu <marongiu.lu...@gmail.com> a
> > >> écrit :
> > >>
> > >> I got the same errors:
> > >> ```
> > >>> library(basicdrm)
> > >>> findBestHill(Response~Dose, df)
> > >> Error in findBestHill(Response ~ Dose, df) :
> > >> could not find function "findBestHill"
> > >>> evalHillEqn(Response~Dose, df)
> > >> Error in evalHillEqn(Response ~ Dose, df) :
> > >> could not find function "evalHillEqn"
> > >> ```
> > >>
> > >>>> On Wed, Sep 24, 2025 at 1:47 PM peter dalgaard <pda...@gmail.com>
> > >>>> wrote:
> > >>>
> > >>> They're in basicdrm, not braidrm...
> > >>>
> > >>> -pd
> > >>>
> > >>>>> On 24 Sep 2025, at 11:52 , Luigi Marongiu <marongiu.lu...@gmail.com>
> > >>>>> wrote:
> > >>>>
> > >>>> Hello,
> > >>>> I have a set of data coming from a dissociation experiment
> > >>>> (protein/ligand). Since the data is required to calculate the constant
> > >>>> of dissociation (Kd) of this pair, I am looking for a way of fitting a
> > >>>> Hill function to the data.
> > >>>> I have seen that the package braidrm
> > >>>> (https://cran.r-project.org/web/packages/braidrm/index.html) provides
> > >>>> this function, but when I launch the function `evalHillEqn`,
> > >>>> `findBestHill` and so forth I get the error of function not found.
> > >>>> Yet, the package is given as properly installed by the system.
> > >>>> How can I run this package?
> > >>>> Is there an alternative way to fit a Hill function to these data?
> > >>>> Thank you
> > >>>>
> > >>>> ```
> > >>>> df = data.frame(Response = c(890.72, 895.46, 895.63,
> > >>>> 894.72, 895.49, 893.59,
> > >>>> 892.53, 895.06, 897.21, 889.27, 876.05,
> > >>>> 857.96, 862.02, 858.36,
> > >>>> 890.94, 890.8, 887.22, 888.91, 890.83,
> > >>>> 889.92, 891.76, 890.32,
> > >>>> 886.35, 878.11, 866.57, 859.04, 863.64,
> > >>>> 880.16, 884.15, 879.57,
> > >>>> 878.89, 882.27, 881.59, 880.98, 881.45,
> > >>>> 876.19, 868.32, 859.16,
> > >>>> 850.53, 853.21, 859.34, 859.73, 861.19),
> > >>>> Dose = c(0.0000000015, 0.000000003,
> > >>>> 0.000000006, 0.000000012,
> > >>>> 0.000000024, 0.000000048, 0.000000095,
> > >>>> 0.00000018,
> > >>>> 0.00000038, 0.00000078, 0.0000015,
> > >>>> 0.000013, 0.000025,
> > >>>> 0.00005, 0.0000000015, 0.000000003,
> > >>>> 0.000000006,
> > >>>> 0.000000012, 0.000000024, 0.000000048,
> > >>>> 0.000000095,
> > >>>> 0.00000018, 0.00000038, 0.00000078,
> > >>>> 0.0000015, 0.000025,
> > >>>> 0.00005, 0.0000000015, 0.000000003,
> > >>>> 0.000000006,
> > >>>> 0.000000012, 0.000000024, 0.000000048,
> > >>>> 0.000000095,
> > >>>> 0.00000018, 0.00000038, 0.00000078,
> > >>>> 0.0000015, 0.000003,
> > >>>> 0.000006, 0.000013, 0.000025, 0.00005)
> > >>>> )
> > >>>> plot(Response~log10(Dose), df)
> > >>>> library(braidrm)
> > >>>> evalHillEqn(Response~Dose, df)
> > >>>> findBestHill(Response~Dose, df)
> > >>>> ```
> > >>>>
> > >>>> ______________________________________________
> > >>>> R-help@r-project.org mailing list -- To UNSUBSCRIBE and more, see
> > >>>> https://stat.ethz.ch/mailman/listinfo/r-help
> > >>>> PLEASE do read the posting guide
> > >>>> https://www.R-project.org/posting-guide.html
> > >>>> and provide commented, minimal, self-contained, reproducible code.
> > >>>
> > >>> --
> > >>> Peter Dalgaard, Professor,
> > >>> Center for Statistics, Copenhagen Business School
> > >>> Solbjerg Plads 3, 2000 Frederiksberg, Denmark
> > >>> Phone: (+45)38153501
> > >>> Office: A 4.23
> > >>> Email: pd....@cbs.dk Priv: pda...@gmail.com
> > >>>
> > >>
> > >>
> > >> --
> > >> Best regards,
> > >> Luigi
> > >>
> > >> ______________________________________________
> > >> R-help@r-project.org mailing list -- To UNSUBSCRIBE and more, see
> > >> https://stat.ethz.ch/mailman/listinfo/r-help
> > >> PLEASE do read the posting guide
> > >> https://www.R-project.org/posting-guide.html
> > >> and provide commented, minimal, self-contained, reproducible code.
> > >
> > > [[alternative HTML version deleted]]
> > >
> > > ______________________________________________
> > > R-help@r-project.org mailing list -- To UNSUBSCRIBE and more, see
> > > https://stat.ethz.ch/mailman/listinfo/r-help
> > > PLEASE do read the posting guide
> > > https://www.R-project.org/posting-guide.html
> > > and provide commented, minimal, self-contained, reproducible code.
> >
>
>
> --
> Best regards,
> Luigi
--
Best regards,
Luigi
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