when I tried to install oligo package by if (!requireNamespace("BiocManager", quietly = TRUE))
install.packages("BiocManager") BiocManager::install("oligo It gives me the following eroor: Warning messages: 1: In file.copy(savedcopy, lib, recursive = TRUE) : problem copying C:\Users\USER\Documents\R\win-library\4.0\00LOCK\bit\libs\x64\bit.dll to C:\Users\USER\Documents\R\win-library\4.0\bit\libs\x64\bit.dll: Permission denied 2: In file.copy(savedcopy, lib, recursive = TRUE) : problem copying C:\Users\USER\Documents\R\win-library\4.0\00LOCK\matrixStats\libs\x64\matrixStats.dll to C:\Users\USER\Documents\R\win-library\4.0\matrixStats\libs\x64\matrixStats.dll: Permission denied Also when i tried to: #Load the target files which the information about the sample and their corresponding group by targets<-read.delim(file="targets.txt", header=T)and create design and fit the design by design <- model.matrix(~0+ conditions) It gives me the error : Error in model.frame.default(object, data, xlev = xlev) : invalid type (closure) for variable 'conditions' [[alternative HTML version deleted]] ______________________________________________ R-help@r-project.org mailing list -- To UNSUBSCRIBE and more, see https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting-guide.html and provide commented, minimal, self-contained, reproducible code.