Dear Ana

Since this appears to be genetics data have you thought of looking at Bioconductor for help? I do not use genetic data-sets but people there must use big files every day three times before breakfast.

Michael

On 24/10/2019 00:33, Ana Marija wrote:
thanks but I would need solution in R

On Wed, Oct 23, 2019 at 6:31 PM Jim Lemon <drjimle...@gmail.com> wrote:

I don't have it installed - that was merely a suggestion. I notice
that both data.table and dplyr packages are mentioned as possibilities
for "merge big datasets in r". Apparently the best way to do it if you
have a database manager is to read the two datasets into tables and do
the join via SQL or whatever language is available.

Jim

On Thu, Oct 24, 2019 at 10:17 AM Ana Marija <sokovic.anamar...@gmail.com> wrote:

no can you please send me an example how the command would look like in my case?

On Wed, Oct 23, 2019 at 6:16 PM Jim Lemon <drjimle...@gmail.com> wrote:

Yes. Have you tried the bigmemory package?

Jim

On Thu, Oct 24, 2019 at 10:08 AM Ana Marija <sokovic.anamar...@gmail.com> wrote:

Hi Jim,

I think one of the issue is that data frames are so big,
dim(l4)
[1] 166941635         8
dim(asign)
[1] 107371528         5

so my example would not reproduce the error

On Wed, Oct 23, 2019 at 6:05 PM Jim Lemon <drjimle...@gmail.com> wrote:

Hi Ana,
When I run this example taken from your email:

l4<-read.table(text="X1 X2 X3 X4  X5 variant_id pval_nominal gene_id.LCL
chr1 13550  G  A b38 1:13550:G:A     0.375614 ENSG00000227232
chr1 14671  G  C b38 1:14671:G:C     0.474708 ENSG00000227232
chr1 14677  G  A b38 1:14677:G:A     0.699887 ENSG00000227232
chr1 16841  G  T b38 1:16841:G:T     0.127895 ENSG00000227232
chr1 16856  A  G b38 1:16856:A:G     0.627822 ENSG00000227232
chr1 17005  A  G b38 1:17005:A:G     0.802803 ENSG00000227232",
header=TRUE,stringsAsFactors=FALSE)
asign<-read.table(text="gene  chr  chr_pos   pos p.val.Retina
ENSG00000227232 chr1           1:10177:A:AC 10177     0.381708
ENSG00000227232 chr1 rs145072688:10352:T:TA 10352     0.959523
ENSG00000227232 chr1            1:11008:C:G 11008     0.218132
ENSG00000227232 chr1            1:11012:C:G 11012     0.218132
ENSG00000227232 chr1            1:13110:G:A 13110     0.998262
ENSG00000227232 chr1  rs201725126:13116:T:G 13116     0.438572",
header=TRUE,stringsAsFactors=FALSE)
merge(l4, asign, by.x=c("X1", "X2"), by.y=c("chr", "pos"))
  [1] X1           X2           X3           X4           X5
[6] variant_id   pval_nominal gene_id.LCL  gene         chr_pos
[11] p.val.Retina
<0 rows> (or 0-length row.names)

It works okay, but there are no matches in the join. So I can't even
guess what the problem is.

Jim

On Thu, Oct 24, 2019 at 9:33 AM Ana Marija <sokovic.anamar...@gmail.com> wrote:

Hello,

I have two data frames like this:

head(l4)
     X1    X2 X3 X4  X5  variant_id pval_nominal     gene_id.LCL
1 chr1 13550  G  A b38 1:13550:G:A     0.375614 ENSG00000227232
2 chr1 14671  G  C b38 1:14671:G:C     0.474708 ENSG00000227232
3 chr1 14677  G  A b38 1:14677:G:A     0.699887 ENSG00000227232
4 chr1 16841  G  T b38 1:16841:G:T     0.127895 ENSG00000227232
5 chr1 16856  A  G b38 1:16856:A:G     0.627822 ENSG00000227232
6 chr1 17005  A  G b38 1:17005:A:G     0.802803 ENSG00000227232
head(asign)
               gene  chr                chr_pos   pos p.val.Retina
1: ENSG00000227232 chr1           1:10177:A:AC 10177     0.381708
2: ENSG00000227232 chr1 rs145072688:10352:T:TA 10352     0.959523
3: ENSG00000227232 chr1            1:11008:C:G 11008     0.218132
4: ENSG00000227232 chr1            1:11012:C:G 11012     0.218132
5: ENSG00000227232 chr1            1:13110:G:A 13110     0.998262
6: ENSG00000227232 chr1  rs201725126:13116:T:G 13116     0.438572
m = merge(l4, asign, by.x=c("X1", "X2"), by.y=c("chr", "pos"))
Error in merge.data.frame(l4, asign, by.x = c("X1", "X2"), by.y = c("chr",  :
   negative length vectors are not allowed
sapply(l4,class)
           X1           X2           X3           X4           X5   variant_id
  "character"  "character"  "character"  "character"  "character"  "character"
pval_nominal  gene_id.LCL
    "numeric"  "character"
sapply(asign,class)
         gene          chr      chr_pos          pos p.val.Retina
  "character"  "character"  "character"  "character"  "character"

Please advise as to why I am getting this error when merging?

Thanks
Ana

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--
Michael
http://www.dewey.myzen.co.uk/home.html

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