Hi all,
I would like to introduce you to a new package available on CRAN for
performing meta-analysis of dose-response relationships, 'MBNMAdose'.
For anyone who has performed a meta-analysis or network meta-analysis
before, you might be aware of the difficulties of including different doses
of a drug. Typically one either assumes that different doses have a broadly
similar effect, or that they are totally independent.
MBNMAdose allows you to explicitly model the dose-response relationship in
a statistically robust framework. By modelling dose-response relationships
this can connect networks of evidence that might otherwise be disconnected,
and can improve precision on treatment estimates.
There's a detailed vignette included with the package that explains
everything in a lot more detail for those that are interested.
Any feedback or suggestions for improvements would be hugely welcome.
Many thanks,
Hugo
Hugo Pedder
Senior Research Associate
Population Health Sciences
University of Bristol
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