Dear all,I have studied “Mixed models in R using the lme4 package Part 6:
Nonlinear mixed models” by Douglas Bates. In this tutorial, there are some
codes to fit nonlinear mixed models for Theoph data. The codes are as fallows:
>Th. start <- c(lKe = -2.5, lKa = 0.5 , lCl = -3)> nm1 <- nlmer ( conc ~ SSfol
(Dose , Time ,lKe , lKa , lCl) ~+ 0+ lKe+lKa+lCl +(0+ lKe| Subject )+(0+
lKa| Subject )+ +(0+ lCl| Subject ), nAGQ =0, Theoph ,+ start = Th.start
, verbose = TRUE )
I want to add a covariate (like age) to CL parameter. How should I modify
above codes? what's more, how are selected initial values (lKe = -2.5, lKa =
0.5 , lCl = -3) ?
Thanks in advanceElham
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