Can you try to compile your .Rmd file in the R console (instead of clicking the button in RStudio)?
rmarkdown::render('your.Rmd') If it gives the same error, please post the traceback() information. I just tried the following minimal example, and I was unable to reproduce your problem. You may also try to reinstall the package: BiocInstaller::biocLite('IlluminaHumanMethylation450kanno.ilmn12.hg19') --- output: pdf_document --- ```{r} library(IlluminaHumanMethylation450kanno.ilmn12.hg19) data(IlluminaHumanMethylation450kanno.ilmn12.hg19) ``` Regards, Yihui -- Yihui Xie <xieyi...@gmail.com> Web: http://yihui.name On Mon, Jan 12, 2015 at 12:06 AM, Molly Elliott <ellio...@onid.oregonstate.edu> wrote: > R version: 3.1.2 (2014-10-31) > RStudio version: 0.98.1091 > MacOS X Yosemite v. 10.10.1 > > When I run the following in the console, all is well: > data(IlluminaHumanMethylation450kanno.ilmn12.hg19) > > Yet, when I compile in my .Rmd file, in RStudio (knit to PDF), I get the > following error: > Error in file(file, "rt") : cannot open the connection > Calls: <Anonymous> ... withVisible -> eval -> eval -> read.delim -> > read.table -> file > Execution halted > > From what I have read, this could be alleviated by pointing the the source > file for data(IlluminaHumanMethylation450kanno.ilmn12.hg19) as opposed to > LazyLoading with the data() function. Yet, I’m not sure how to work around > this. (This is my first R project ever) The > data(IlluminaHumanMethylation450kanno.ilmn12.hg19) is just loading an > annotation file from library(IlluminaHumanMethylation450kanno.ilmn12.hg19), > and I’m not sure of the file type the data are stored under (.txt, .csv, etc). > > Thanks in advance! > > Molly ______________________________________________ R-help@r-project.org mailing list -- To UNSUBSCRIBE and more, see https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting-guide.html and provide commented, minimal, self-contained, reproducible code.