You posted this earlier. Do not repost, please. It was seen.

-- Bert

On Mon, Mar 18, 2013 at 3:28 PM, To . . <kid...@hotmail.com> wrote:

>
> Hello
>
> I am trying to find an automated way of fitting a mixture of normal and
> log-normal distributions to data which is clearly bimodal.
> Here's a simulated example:
> x.1<-rnorm(6000, 2.4, 0.6)
> x.2<-rlnorm(10000, 1.3,0.1)
> X<-c(x.1, x.2)
> hist(X,100,freq=FALSE, ylim=c(0,1.5))lines(density(x.1), lty=2, lwd=2)
> lines(density(x.2), lty=2, lwd=2)
> lines(density(X), lty=4)
>
> Currently i am using mixtools and just run:
> library(mixtools)
> mixmdl = normalmixEM(X, k=2, epsilon = 1e-08, maxit = 1000,
> maxrestarts=20, verb = TRUE, fast=FALSE, ECM = FALSE, arbmean = TRUE,
> arbvar = TRUE)
> plot(mixmdl,which=2)lines(density(X), lty=2, lwd=2)
>
> This is obviously not the best way of doing this.
> The estimates it gives are:
> mu 3.6595737(x.2 log()=1.29) 2.3113135(x.1)
>
> These are not too far off but I was wondering if someone knows of a better
> R package/way of doing this or has any hints that would help me coding it
> from scratch (EM+writing down the formulae for ML? but... would this really
> be better than using a
> "more-advanced-already-available-package-made-by-pros"?).
> The objective is to estimate threshold values at specific FDRs. (some help
> with that would also be most helpful.)
>
> Thanks to all in advance!
> To'
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>



-- 

Bert Gunter
Genentech Nonclinical Biostatistics

Internal Contact Info:
Phone: 467-7374
Website:
http://pharmadevelopment.roche.com/index/pdb/pdb-functional-groups/pdb-biostatistics/pdb-ncb-home.htm

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