Hi,
I am looking for the best way or best package available for simulating a
genetic association between a specific SNP and a quantitative
phenotype. All of the packages I saw in R seem to be specialised in
pedigree data or in population data where coalescence and other
evolutionary factors are specified, but I don't have any experience in
population genetics and I only want to simulate the simple case of European
population which is the most similar to my real data, having a normal
distribution for the trait and an additive effect for the genotype.
I am looking for something in R similar to the function in Plink where one
needs to specify a range of allele frequencies, a range for the phenotype,
and a variant which should result associated with the genotype.
Can someone please help me?
Thank you very much.
James
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