Let me expand a bit on Thomas's answer. Looking more closely at your data set you have the following:
death time group 0 group 1 1.5 0/4 13/13 3 0/4 5/5 8 4/4 0 At time 1.5 group 1 had 13 deaths out of 13 at risk, group 0 had none. Time 8 doesn't have any impact on the fit, since only one group was at risk the deaths are guarranteed to come from that group. So the actual MLE for the hazard ratio is 1/0 = infinity, 100% death rate in group 1 vs. 0% in group 0, at all the time points where the two groups can be compared. Section 3.5 of Therneau and Grambsch, Extending the Cox Model, has a picture of the log-likelihood in such a case, which very quickly approaches an asymptote as beta goes to infinity. Both phreg and coxph iterate until the loglik "doesn't change anymore". The printed solution depends entirely on the convergence criteria, which are slightly different in the two programs. I chose to add a warning message. Final note: I never use the discrete option, having found the Efron approximation to be sufficient in every practical situation. Partly for that reason I have not worked very hard at optimising the code for that case while SAS has. If you insist on using the exact partial likelihood then phreg will be tens to thousands of times faster: my code is O(2^d) compute time where d=the max # of tied deaths at one time and theirs is polynomial in d. I doubt that coxph ever "crashes" your computer, but it is easy to construct a data set whose compute time is in days or even years. Terry Therneau ______________________________________________ R-help@r-project.org mailing list https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting-guide.html and provide commented, minimal, self-contained, reproducible code.