Hello, I'm also working on a QSAR validation, and would like to confirm that my multiple least squares regression based on only 4 x-variables out of a pool of 300 x-variables is significant. I want to apply the y-randomization or y-scrambling permutation protocol using R, but I have not been able to find any examples that are similar to my problem. Could someone clarify whether this type of validation protocol could be done with the R 'boostrap' function, or 'onetPermutation' or 'sample'? I'm not a statistician and I'm having a hard time deciphering the code and explanations in the manual, so help would be greatly appreciated!!!! Thanks!!
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