Sounds like you want to use the filehash package which was written for just
such problems

http://yusung.blogspot.com/2007/09/dealing-with-large-data-set-in-r.html
http://cran.r-project.org/web/packages/filehash/index.html


or maybe the ff package
http://cran.r-project.org/web/packages/ff/index.html

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