Hi,
I am trying fit my kinetic data with the "mkin" package. There I have two
questions:
1.) I would like to fix the parameter parent_0, the concentration of the parent
at time 0. In the mkinfit function description it says you can do it with the
arguments parms.ini and fixed_parms. In which form do these arguments have to
be to fix the (internally defined and fitted) parameter parent_0?
SFO <- mkinmod(parent=list(type="SFO"))
SFO.fit <- mkinfit(SFO,data, parm.ini=??, fixed_parms=??)
2.) When I try to fit the parent and a metabolite m1, I get the error message:
Error in dnorm(x, mean, sd, log) :
Non-numeric argument to mathematical function
In addition: Warning messages:
1: In Ops.factor(ModVar, obsdat) : - not meaningful for factors
2: In Ops.factor(ModVar, obsdat) : - not meaningful for factors
My code is:
data <- read.table("101025_batch1.txt", header=TRUE)
SFO_SFO <- mkinmod(parent = list(type = "SFO", to = "m1", sink =TRUE),m1 =
list(type = "SFO"))
SFO.fit <- mkinfit(SFO_SFO,data)
101025_batch1.txt looks like this:
name time value
parent 0 NA
parent 15 NA
parent 29 23.796
parent 44 14.499
parent 58 7.650
parent 73 4.170
parent 88 2.438
parent 102 1.865
parent 117 1.598
m1 0 0
m1 15 6.476
m1 29 19.651
m1 44 32.271
m1 58 40.906
m1 73 48.295
m1 88 53.295
m1 102 56.250
m1 117 58.459
Thank you very much for you help!
Rebekka
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