I came across a post by Karl Knoblick regarding the modeling of longitudinal
data (see https://stat.ethz.ch/pipermail/r-help/2007-May/132137.html). I am
often asked by physicians to perform what Karl refers to in his post as option
1: to perform paired t-tests against baseline at each follow up time point (30
days, 90 days, 6 months, etc.). Unlike Karl's example, however, many of the
trials I am involved in are one-armed (so there are no across-trial-arms
comparisons).
No matter how hard I try to explain to physicians why this approach is not the
best, it has typically been to no avail. I am wondering if anyone knows of a
paper I can quote instead? One (or more) from the cardiovascular literature
would be especially precious to me.
Best regards,
-Cody Hamilton
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