Yes! It is. Just make your GUI in C# and assign event handlers using Python for .NET http://www.zope.org/Members/Brian/PythonNet/
Python for .NET is a great tool and has a minimal learning curve. Unfortunately, it hasn't attracted enough attention from the Python community. It does not have a .NET 2.0 release yet but it is in the works. Or you could use Boo with SharpDevelop. You will get Visual form design with a very Pythonic language. But you won't get to use Python libraries. IronPython is getting IDE integration in the CTP releases for Visual Studio. Maybe it will support form design in the future. I have not tried it yet. -- http://mail.python.org/mailman/listinfo/python-list
