I suggest checking out PythonCard. It's a GUI builder based on wxPython and it's very easy to use. It offers the basic functionality of Delphi or VB, letting you drag & drop widgets on a form. This visual way of dealing with widgets authomatically creates a file with the form and its controls description, and the events associated to these widgets are writen in another separated file as simple functions.
http://pythoncard.sourceforge.net/ -- http://mail.python.org/mailman/listinfo/python-list
