> Can I use Pickle to store about 500,000 key value pairs.. or should I
> use mySql. Which one is best for performance, as the key value pair
> increases.

Pickle: absolutely out of the question.
Mysql: might work, albeit slowly.

Use berkeley DB (bsddb3), or zodb.  I have no experience with the
latter, but bdb's scale far beyond that magnitude if necessary.

-Mike

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