see vb2py to help the conversion http://vb2py.sourceforge.net/ or if you want to convert vb6 to vb.net instead, there are tools from microsoft and others to help with that, such as: http://www.microsoft.com/downloads/details.aspx?FamilyId=10C491A2-FC67-4509-BC10-60C5C039A272&displaylang=en
or if you want to start over from scratch, the other recommendations are good, like pyqt and qt designer, or else do it as a web app instead of desktop app if it just involves basic form controls. -- http://mail.python.org/mailman/listinfo/python-list