With some good guidance, it goes much more smooth than I thought, even for a total Mac newbie like me. For example to install the latest Python 2.4.2 and wxPython2.6 on the Mac was very easy. You can find instructions in the SPE Python IDE manual and also how to install SPE on the Mac in case you want a full featured IDE as well: http://pythonide.stani.be/manual/html/manual2.html
Here as well you'll find a lot of installers as well for MacOS X: http://pythonmac.org/packages/ Good luck, Stani -- http://pythonide.stani.be -- http://mail.python.org/mailman/listinfo/python-list